MGA (MAX dimerization protein MGA)

2014-01-01  

Identity

HGNC
MGA
LOCATION
15q15.1
LOCUSID
23269
ALIAS
MAD5,MXD5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23269
MIM: 616061
HGNC: 14010
Ensembl: ENSG00000174197

Variants:

dbSNP: 23269
ClinVar: 23269
TCGA: ENSG00000174197
COSMIC: MGA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174197ENST00000219905Q8IWI9
ENSG00000174197ENST00000545763Q8IWI9
ENSG00000174197ENST00000561532H3BTN2
ENSG00000174197ENST00000563576H3BTF4
ENSG00000174197ENST00000564190H3BU53
ENSG00000174197ENST00000566586Q8IWI9
ENSG00000174197ENST00000566718H3BP52
ENSG00000174197ENST00000570161Q8IWI9
ENSG00000174197ENST00000619521A0A087X194

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
243622642014MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1.56
241312482014TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection.26
295251832018LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways.6
262723892015Generation of monoclonal antibodies against MGA and comparison of their application in breast cancer detection by immunohistochemistry.3
273065722016Somatic mutation of a candidate tumour suppressor MGA gene and its mutational heterogeneity in colorectal cancers.3

Citation

Dessen P

MGA (MAX dimerization protein MGA)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53659/mga