MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase)

2013-03-01  

Identity

HGNC
MGAT1
LOCATION
5q35.3
LOCUSID
4245
ALIAS
GLCNAC-TI,GLCT1,GLYT1,GNT-1,GNT-I,GnTI,MGAT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4245
MIM: 160995
HGNC: 7044
Ensembl: ENSG00000131446

Variants:

dbSNP: 4245
ClinVar: 4245
TCGA: ENSG00000131446
COSMIC: MGAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131446ENST00000307826P26572
ENSG00000131446ENST00000333055P26572
ENSG00000131446ENST00000393340P26572
ENSG00000131446ENST00000427865P26572
ENSG00000131446ENST00000446023P26572
ENSG00000131446ENST00000502678D6RBS3
ENSG00000131446ENST00000504671D6RF69
ENSG00000131446ENST00000506269D6R9U2
ENSG00000131446ENST00000506889D6RHZ8
ENSG00000131446ENST00000507384D6RIS2
ENSG00000131446ENST00000512695D6RD15
ENSG00000131446ENST00000513431D6RA48
ENSG00000131446ENST00000514283D6RB69
ENSG00000131446ENST00000514438D6RAK2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan trimming and elongation in the cis-GolgiREACTOMER-HSA-964739

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192198572009Genetic association studies of methamphetamine use disorders: A systematic review and synthesis.29
198512992010Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.19
198512992010Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.19
229570332012Suppression of cancer progression by MGAT1 shRNA knockdown.14
267332892016Classical galactosaemia: novel insights in IgG N-glycosylation and N-glycan biosynthesis.14
259449012015UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats).11
263718702015GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain.8
213044852012Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children.6
245727422014Family studies of type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms.5
293106262018MGAT1 is a novel transcriptional target of Wnt/β-catenin signaling pathway.3

Citation

Dessen P

MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53198/mgat1