MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A)

2007-02-01  

Identity

HGNC
LOCATION
2q11.2
LOCUSID
ALIAS
GNT-IV,GNT-IVA,GnT-4a
FUSION GENES

Other Information

Locus ID:

NCBI: 11320
MIM: 604623
HGNC: 7047
Ensembl: ENSG00000071073

Variants:

dbSNP: 11320
ClinVar: 11320
TCGA: ENSG00000071073
COSMIC: MGAT4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071073ENST00000264968Q9UM21
ENSG00000071073ENST00000393487Q9UM21
ENSG00000071073ENST00000409391Q9UM21
ENSG00000071073ENST00000414521Q9UM21
ENSG00000071073ENST00000495056U3KPT4

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
N-glycan biosynthesis, complex typeKEGGhsa_M00075
N-glycan biosynthesis, complex typeKEGGM00075
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
N-Glycan antennae elongationREACTOMER-HSA-975577

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10040cetuximabChemicalClinicalAnnotationassociatedPD26222057
PA130232992bevacizumabChemicalClinicalAnnotationassociatedPD26222057
PA131285527oxaliplatinChemicalClinicalAnnotationassociatedPD26222057
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD26222057
PA448771capecitabineChemicalClinicalAnnotationassociatedPD26222057

References

Pubmed IDYearTitleCitations
156883872005Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma.26
174885272007N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma.18
164340232006Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer.13
265897992016MicroRNA-424 Predicts a Role for β-1,4 Branched Glycosylation in Cell Cycle Progression.10
170066392006Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes.9
231693002012High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.7
197514372009Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk.3
179537602007The transcription of MGAT4A glycosyl transferase is increased in white cells of peripheral blood of type 2 diabetes patients.2
285349632017N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.0

Citation

Dessen P

MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43659/mgat4a