MGMT (O-6-methylguanine-DNA methyltransferase)

2003-02-01  

Identity

HGNC
LOCATION
10q26.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 4255
MIM: 156569
HGNC: 7059
Ensembl: ENSG00000170430

Variants:

dbSNP: 4255
ClinVar: 4255
TCGA: ENSG00000170430
COSMIC: MGMT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170430ENST00000306010B4DEE8
ENSG00000170430ENST00000651593P16455

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Damage ReversalREACTOMER-HSA-73942
MGMT-mediated DNA damage reversalREACTOMER-HSA-5657655

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451609temozolomideChemicalMultilinkAnnotationassociated24444404

References

Pubmed IDYearTitleCitations
251639062014Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial.231
184458442008MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients.191
150417002004Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide.183
161748542005MGMT promoter methylation and field defect in sporadic colorectal cancer.176
198056722009Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network.175
161952372006Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.112
185162902008PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations.111
162037972005Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.104
185091812008Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial.96
203099622010Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma.95

Citation

Dessen P

MGMT (O-6-methylguanine-DNA methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/416/mgmt