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MGMT (O-6-methylguanine-DNA methyltransferase)

Identity

Other names-
HGNC (Hugo) MGMT
Location 10q26.3
Location_base_pair Starts at 131155444 and ends at 131455773 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MGMT   7059
Entrez_Gene (NCBI)MGMT  4255  O-6-methylguanine-DNA methyltransferase
Cards
GeneCards (Weizmann)MGMT
Ensembl (Hinxton)ENSG00000170430 [Gene_View]  MGMT [Vega]
AceView (NCBI)MGMT
Genatlas (Paris)MGMT
euGene (Indiana)4255
SOURCE (Stanford)NM_002412
Gene Expression (Array Express) ENSG00000170430
Genomic and cartography
GoldenPath (UCSC)MGMT  -  10q26.3   chr10:131155444-131455773 +  10q26.3   [Description]    (hg18-March_2006)
EnsemblMGMT - 10q26.3 [CytoView]
Mapping of homologs : NCBIMGMT [Mapview]
OMIM156569   
Gene and transcription
Gene : Genbank (Entrez)AK293593 BC000824 BI520029 BT006714 CR599817
Reference sequence (RefSeq transcript) :SRSNM_002412
Reference transcript : EntrezNM_002412
RefSeq genomic : SRSAC_000053 AC_000142 NC_000010 NT_008818 NW_001838011 NW_924884
RefSeq genomic : EntrezAC_000053 AC_000142 NC_000010 NT_008818 NW_001838011 NW_924884
Consensus coding sequences : CCDS NCBIMGMT
Cluster EST : UnigeneHs.501522 [ SRS ] Hs.501522 [ NCBI ]
Alternative Splicing : Fast-db (Paris)17091
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP16455 (SRS) P16455 (Expasy) P16455 (Uniprot)
With graphics : InterProP16455
Splice isoforms : VarSplice FASTAP16455(VarSplice FASTA)
Domaine pattern : Prosite (SRS)MGMT (PS00374)   
Domain pattern : Prosite (Expaxy)MGMT (PS00374)   
Domains : Interpro (SRS)MethylDNA_cys_MeTrfase_AS    MethylDNA_cys_MeTrfase_DNA_bd    MethylG_MeTrfase    Wing_hlx_DNA_bd   
Domains : Interpro (EBI)MethylDNA_cys_MeTrfase_AS    MethylDNA_cys_MeTrfase_DNA_bd    MethylG_MeTrfase    Wing_hlx_DNA_bd   
Related proteins : CluSTrP16455
Domain families : Pfam SRSDNA_binding_1 (PF01035)    Methyltransf_1N (PF02870)   
Domain families : Pfam SangerDNA_binding_1 (PF01035)    Methyltransf_1N (PF02870)   
Domain families : Pfam NCBIpfam01035    pfam02870   
Blocks (Seattle)P16455
Crystal structure of protein : PDB SRS1EH6    1EH7    1EH8    1QNT    1T38    1T39    1YFH   
Crystal structure of protein : PDBSum1EH6    1EH7    1EH8    1QNT    1T38    1T39    1YFH   
Crystal structure of protein : IMB1EH6    1EH7    1EH8    1QNT    1T38    1T39    1YFH   
Crystal structure of protein : PDB RSDB1EH6    1EH7    1EH8    1QNT    1T38    1T39    1YFH   
HPRD01135
Protein Interaction databases
DIP (DOE-UCLA)P16455
IntAct (EBI)P16455
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIMGMT
SNP : GeneSNP UtahMGMT
SNP : HGBaseMGMT
Genetic variants : HAPMAPMGMT
Somatic Mutations in Cancer : COSMICMGMT 
Mutations and Diseases : HGMDMGMT
Hereditary diseases : OMIM156569   
Hereditary diseases : GENETests156569   
Diseases : Genetic AssociationMGMT
General knowledge
Homologs : HomoloGeneMGMT
Homology/Alignments : Family Browser UCSCMGMT
Phylogenetic Trees/Animal Genes : TreeFamMGMT
Catalytic activity : Enzyme2.1.1.63 [ Enzyme-Expasy ]   2.1.1.63 [ Enzyme-SRS ]   2.1.1.63 [ IntEnz-EBI ]   2.1.1.63 [ BRENDA ]   2.1.1.63 [ KEGG ]   
Chemical/Protein Interactions : CTD4255
Keywords Ontology : AmiGODNA binding  methylated-DNA-[protein]-cysteine S-methyltransferase activity  nucleus  nucleoplasm  DNA ligation  DNA dealkylation  response to DNA damage stimulus  zinc ion binding  DNA-methyltransferase activity  transferase activity  regulation of caspase activity  metal ion binding  
Keywords Ontology : EGO-EBIDNA binding  methylated-DNA-[protein]-cysteine S-methyltransferase activity  nucleus  nucleoplasm  DNA ligation  DNA dealkylation  response to DNA damage stimulus  zinc ion binding  DNA-methyltransferase activity  transferase activity  regulation of caspase activity  metal ion binding  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesMGMT Related clones (RZPD - Berlin)
Literature
PubMed240 Pubmed reference(s) in Entrez
PubGeneMGMT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

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indexed on : Sat Feb 27 10:29:50 CET 2010
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