Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MGST2 (microsomal glutathione S-transferase 2)

Identity

Alias_symbol (synonym)MGST-II
Other aliasGST2
HGNC (Hugo) MGST2
LocusID (NCBI) 4258
Atlas_Id 54455
Location 4q31.1  [Link to chromosome band 4q31]
Location_base_pair Starts at 139665768 and ends at 139704252 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYFIP2 (5q33.3) / MGST2 (4q31.1)MGST2 (4q31.1) / PRDX6 (1q25.1)SESN1 (6q21) / MGST2 (4q31.1)
TCF12 (15q21.3) / MGST2 (4q31.1)TCF12 15q21.3 / MGST2 4q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(4;6)(q31;q21) SESN1/MGST2
t(4;15)(q31;q21) TCF12/MGST2

External links

Nomenclature
HGNC (Hugo)MGST2   7063
Cards
Entrez_Gene (NCBI)MGST2  4258  microsomal glutathione S-transferase 2
AliasesGST2; MGST-II
GeneCards (Weizmann)MGST2
Ensembl hg19 (Hinxton)ENSG00000085871 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000085871 [Gene_View]  ENSG00000085871 [Sequence]  chr4:139665768-139704252 [Contig_View]  MGST2 [Vega]
ICGC DataPortalENSG00000085871
TCGA cBioPortalMGST2
AceView (NCBI)MGST2
Genatlas (Paris)MGST2
WikiGenes4258
SOURCE (Princeton)MGST2
Genetics Home Reference (NIH)MGST2
Genomic and cartography
GoldenPath hg38 (UCSC)MGST2  -     chr4:139665768-139704252 +  4q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MGST2  -     4q31.1   [Description]    (hg19-Feb_2009)
GoldenPathMGST2 - 4q31.1 [CytoView hg19]  MGST2 - 4q31.1 [CytoView hg38]
ImmunoBaseENSG00000085871
Mapping of homologs : NCBIMGST2 [Mapview hg19]  MGST2 [Mapview hg38]
OMIM601733   
Gene and transcription
Genbank (Entrez)AA122237 AK130948 AK307231 BC025416 BE312976
RefSeq transcript (Entrez)NM_001204366 NM_001204367 NM_001204368 NM_002413
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MGST2
Cluster EST : UnigeneHs.81874 [ NCBI ]
CGAP (NCI)Hs.81874
Alternative Splicing GalleryENSG00000085871
Gene ExpressionMGST2 [ NCBI-GEO ]   MGST2 [ EBI - ARRAY_EXPRESS ]   MGST2 [ SEEK ]   MGST2 [ MEM ]
Gene Expression Viewer (FireBrowse)MGST2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4258
GTEX Portal (Tissue expression)MGST2
Human Protein AtlasENSG00000085871-MGST2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99735   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99735  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99735
Splice isoforms : SwissVarQ99735
Catalytic activity : Enzyme2.5.1.18 [ Enzyme-Expasy ]   2.5.1.182.5.1.18 [ IntEnz-EBI ]   2.5.1.18 [ BRENDA ]   2.5.1.18 [ KEGG ]   
PhosPhoSitePlusQ99735
Domaine pattern : Prosite (Expaxy)FLAP_GST2_LTC4S (PS01297)   
Domains : Interpro (EBI)5_LipOase_AP    FLAP/GST2/LTC4S_CS    MAPEG-like_dom_sf    Membr-assoc_MAPEG   
Domain families : Pfam (Sanger)MAPEG (PF01124)   
Domain families : Pfam (NCBI)pfam01124   
Conserved Domain (NCBI)MGST2
DMDM Disease mutations4258
Blocks (Seattle)MGST2
SuperfamilyQ99735
Human Protein Atlas [tissue]ENSG00000085871-MGST2 [tissue]
Peptide AtlasQ99735
HPRD03436
IPIIPI00017767   IPI00982933   IPI00965041   
Protein Interaction databases
DIP (DOE-UCLA)Q99735
IntAct (EBI)Q99735
FunCoupENSG00000085871
BioGRIDMGST2
STRING (EMBL)MGST2
ZODIACMGST2
Ontologies - Pathways
QuickGOQ99735
Ontology : AmiGOglutathione transferase activity  glutathione transferase activity  leukotriene-C4 synthase activity  leukotriene-C4 synthase activity  glutathione peroxidase activity  glutathione peroxidase activity  protein binding  nuclear envelope  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  lipid metabolic process  glutathione biosynthetic process  xenobiotic metabolic process  enzyme activator activity  response to organonitrogen compound  membrane  integral component of membrane  leukotriene biosynthetic process  leukotriene biosynthetic process  response to lipopolysaccharide  positive regulation of catalytic activity  intracellular membrane-bounded organelle  membrane lipid catabolic process  positive regulation of inflammatory response  cellular oxidant detoxification  glutathione derivative biosynthetic process  
Ontology : EGO-EBIglutathione transferase activity  glutathione transferase activity  leukotriene-C4 synthase activity  leukotriene-C4 synthase activity  glutathione peroxidase activity  glutathione peroxidase activity  protein binding  nuclear envelope  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  lipid metabolic process  glutathione biosynthetic process  xenobiotic metabolic process  enzyme activator activity  response to organonitrogen compound  membrane  integral component of membrane  leukotriene biosynthetic process  leukotriene biosynthetic process  response to lipopolysaccharide  positive regulation of catalytic activity  intracellular membrane-bounded organelle  membrane lipid catabolic process  positive regulation of inflammatory response  cellular oxidant detoxification  glutathione derivative biosynthetic process  
Pathways : KEGGGlutathione metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Chemical carcinogenesis   
NDEx NetworkMGST2
Atlas of Cancer Signalling NetworkMGST2
Wikipedia pathwaysMGST2
Orthology - Evolution
OrthoDB4258
GeneTree (enSembl)ENSG00000085871
Phylogenetic Trees/Animal Genes : TreeFamMGST2
HOGENOMQ99735
Homologs : HomoloGeneMGST2
Homology/Alignments : Family Browser (UCSC)MGST2
Gene fusions - Rearrangements
Fusion : MitelmanSESN1/MGST2 [6q21/4q31.1]  [t(4;6)(q31;q21)]  
Fusion : MitelmanTCF12/MGST2 [15q21.3/4q31.1]  [t(4;15)(q31;q21)]  
Fusion PortalTCF12 15q21.3 MGST2 4q31.1 BRCA
Fusion : QuiverMGST2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMGST2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MGST2
dbVarMGST2
ClinVarMGST2
1000_GenomesMGST2 
Exome Variant ServerMGST2
ExAC (Exome Aggregation Consortium)ENSG00000085871
GNOMAD BrowserENSG00000085871
Varsome BrowserMGST2
Genetic variants : HAPMAP4258
Genomic Variants (DGV)MGST2 [DGVbeta]
DECIPHERMGST2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMGST2 
Mutations
ICGC Data PortalMGST2 
TCGA Data PortalMGST2 
Broad Tumor PortalMGST2
OASIS PortalMGST2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMGST2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMGST2
Mutations and Diseases : HGMDMGST2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MGST2
DgiDB (Drug Gene Interaction Database)MGST2
DoCM (Curated mutations)MGST2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MGST2 (select a term)
intoGenMGST2
Cancer3DMGST2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601733   
Orphanet
DisGeNETMGST2
MedgenMGST2
Genetic Testing Registry MGST2
NextProtQ99735 [Medical]
TSGene4258
GENETestsMGST2
Target ValidationMGST2
Huge Navigator MGST2 [HugePedia]
snp3D : Map Gene to Disease4258
BioCentury BCIQMGST2
ClinGenMGST2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4258
Chemical/Pharm GKB GenePA30792
Clinical trialMGST2
Miscellaneous
canSAR (ICR)MGST2 (select the gene name)
DataMed IndexMGST2
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMGST2
EVEXMGST2
GoPubMedMGST2
iHOPMGST2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:53:25 CET 2019
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