MICAL1 (microtubule associated monooxygenase, calponin and LIM domain containing 1)

2015-12-01  

Identity

HGNC
LOCATION
6q21
LOCUSID
ALIAS
MICAL,MICAL-1,NICAL
FUSION GENES

Other Information

Locus ID:

NCBI: 64780
MIM: 607129
HGNC: 20619
Ensembl: ENSG00000135596

Variants:

dbSNP: 64780
ClinVar: 64780
TCGA: ENSG00000135596
COSMIC: MICAL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135596ENST00000358577Q8TDZ2
ENSG00000135596ENST00000358807Q8TDZ2
ENSG00000135596ENST00000431946Q5TED7
ENSG00000135596ENST00000433205H0Y6Z4
ENSG00000135596ENST00000630715Q8TDZ2

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
118279722002MICAL, a novel CasL interacting molecule, associates with vimentin.44
223313572012Differential regulation of actin microfilaments by human MICAL proteins.32
217302912011MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.29
127880692003MICAL-1 isoforms, novel rab1 interacting proteins.27
238344332014MICAL-family proteins: Complex regulators of the actin cytoskeleton.27
255769232015Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells.19
274303082016MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cells.15
282299152017Regulated methionine oxidation by monooxygenases.14
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

MICAL1 (microtubule associated monooxygenase, calponin and LIM domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-12-01

Online version: http://atlasgeneticsoncology.org/gene/55540/mical1