MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2)

2007-02-01  

Identity

HGNC
MICAL2
LOCATION
11p15.3
LOCUSID
9645
ALIAS
Ebitein1,MICAL-2,MICAL2PV1,MICAL2PV2,MICALCL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9645
MIM: 608881
HGNC: 24693
Ensembl: ENSG00000133816

Variants:

dbSNP: 9645
ClinVar: 9645
TCGA: ENSG00000133816
COSMIC: MICAL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133816ENST00000256186Q6ZW33
ENSG00000133816ENST00000256194O94851
ENSG00000133816ENST00000524685E9PNC3
ENSG00000133816ENST00000525119E9PKI3
ENSG00000133816ENST00000526065E9PKW5
ENSG00000133816ENST00000527546O94851
ENSG00000133816ENST00000528931O94851
ENSG00000133816ENST00000529028A0A2R8Y7K9
ENSG00000133816ENST00000532179E9PRE0
ENSG00000133816ENST00000532420E9PJB0
ENSG00000133816ENST00000533389E9PL42
ENSG00000133816ENST00000533534E9PRG5
ENSG00000133816ENST00000646065A0A2R8YFA9
ENSG00000133816ENST00000646734A0A2R8Y771

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
244403342014Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.55
223313572012Differential regulation of actin microfilaments by human MICAL proteins.32
166755692006Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression.20
266899892016MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion.16
308533432019miR-205-5p suppresses pulmonary vascular smooth muscle cell proliferation by targeting MICAL2-mediated Erk1/2 signaling.10
287190452018MICAL2 promotes breast cancer cell migration by maintaining epidermal growth factor receptor (EGFR) stability and EGFR/P38 signalling activation.9
305555472018MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance.2
310047102019MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response.1

Citation

Dessen P

MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46433/mical2