MICB (MHC class I polypeptide-related sequence B)

2007-02-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
PERB11.2
FUSION GENES

Other Information

Locus ID:

NCBI: 4277
MIM: 602436
HGNC: 7091
Ensembl: ENSG00000204516
IMGT/GENE-DB:

Variants:

dbSNP: 4277
ClinVar: 4277
TCGA: ENSG00000204516
COSMIC: MICB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204516ENST00000252229X6R344
ENSG00000204516ENST00000399150Q29980
ENSG00000204516ENST00000538442F5H7Q8

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164749390peginterferon alfa-2aChemicalClinicalAnnotationassociatedPD
PA164784024peginterferon alfa-2bChemicalClinicalAnnotationassociatedPD
PA446863Hepatitis C, ChronicDiseaseClinicalAnnotationassociatedPD
PA451241ribavirinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
123847022002Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.436
176412032007Host immune system gene targeting by a viral miRNA.249
127144932003Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia.133
191159492009Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).119
146628962003Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.87
220017562011Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.86
172023582007Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D.74
125695592003Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid.69
125386832003Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection.66
235264332013Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17.59

Citation

Dessen P

MICB (MHC class I polypeptide-related sequence B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45710/micb