MIEF1 (mitochondrial elongation factor 1)

2016-10-01  

Identity

HGNC
MIEF1
LOCATION
22q13.1
LOCUSID
54471
ALIAS
AltMIEF1,HSU79252,MID51,MIEF1-MP,SMCR7L,dJ1104E15.3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54471
MIM: 615497
HGNC: 25979
Ensembl: ENSG00000100335

Variants:

dbSNP: 54471
ClinVar: 54471
TCGA: ENSG00000100335
COSMIC: MIEF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100335ENST00000325301Q9NQG6
ENSG00000100335ENST00000325301A0A024R1L3
ENSG00000100335ENST00000402881B0QY95
ENSG00000100335ENST00000404569Q9NQG6
ENSG00000100335ENST00000404569A0A024R1L3
ENSG00000100335ENST00000428069Q9NQG6
ENSG00000100335ENST00000433117Q9NQG6
ENSG00000100335ENST00000434364B0QY94

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
232839812013Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.288
215089612011MiD49 and MiD51, new components of the mitochondrial fission machinery.199
215089612011MiD49 and MiD51, new components of the mitochondrial fission machinery.199
217015602011Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission.141
239213782013Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.88
269035402016Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling.57
294316432018Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.22
276603092016The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease.20
238804622013The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics.19
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17

Citation

Dessen P

MIEF1 (mitochondrial elongation factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56068/mief1