MINK1 (misshapen like kinase 1)

2014-11-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
B55,MAP4K6,MINK,YSK2,ZC3
FUSION GENES

Other Information

Locus ID:

NCBI: 50488
MIM: 609426
HGNC: 17565
Ensembl: ENSG00000141503

Variants:

dbSNP: 50488
ClinVar: 50488
TCGA: ENSG00000141503
COSMIC: MINK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141503ENST00000355280Q8N4C8
ENSG00000141503ENST00000571207I3L2I2
ENSG00000141503ENST00000574453I3L4T2
ENSG00000141503ENST00000576037I3L1U1
ENSG00000141503ENST00000577021I3L203
ENSG00000141503ENST00000664602A0A590UJE1

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167602062006Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation.28
154699422004Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta.24
226654852012Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis.23
187521422008Molecular genetic analysis of long QT syndrome in Norway indicating a high prevalence of heterozygous mutation carriers.21
210481372010MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function.21
257475782015The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71.14
171651612006MinK gene polymorphism in the pathogenesis of lone atrial fibrillation.13
220377662012Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation.13
126682602003Mutational study of the nuclear factor kappa B inducing kinase gene in patients with progressive supranuclear palsy.0
311603822019Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics.0

Citation

Dessen P

MINK1 (misshapen like kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68989/mink1