MIOX (myo-inositol oxygenase)

2014-11-01  

Identity

HGNC
MIOX
LOCATION
22q13.33
LOCUSID
55586
ALIAS
ALDRL6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55586
MIM: 606774
HGNC: 14522
Ensembl: ENSG00000100253

Variants:

dbSNP: 55586
ClinVar: 55586
TCGA: ENSG00000100253
COSMIC: MIOX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100253ENST00000216075Q9UGB7
ENSG00000100253ENST00000395732A6PVH2
ENSG00000100253ENST00000395733Q9UGB7
ENSG00000100253ENST00000451761A6PVH4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ascorbate and aldarate metabolismKEGGko00053
Inositol phosphate metabolismKEGGko00562
Ascorbate and aldarate metabolismKEGGhsa00053
Inositol phosphate metabolismKEGGhsa00562

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
117167592001myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol.24
157782192005Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells.17
265785172016Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.11
155043672004Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney.9
282080542017High Glucose-Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy.9
198968702010Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus.6
198968702010Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus.6
305047132018The Kidney Specific Protein myo-Inositol Oxygenase, a Potential Biomarker for Diabetic Nephropathy.1
305396512019Myo-inositol oxygenase accentuates renal tubular injury initiated by endoplasmic reticulum stress.1
291870002018Does myo-inositol oxygenase, the only enzyme to catalyze myo-inositol in vivo, play a role in the etiology of polycystic ovarian syndrome?0

Citation

Dessen P

MIOX (myo-inositol oxygenase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68993/miox