MIR449B (microRNA 449b)

2012-04-01  

Identity

HGNC
MIR449B
LOCATION
5q11.2
LOCUSID
693123
ALIAS
MIRN449B,mir-449b

Other Information

Locus ID:

NCBI: 693123
MIM: 613132
HGNC: 32794
Ensembl: ENSG00000207728
miRBase:

Variants:

dbSNP: 693123
ClinVar: 693123
TCGA: ENSG00000207728
COSMIC: MIR449B

RNA/Proteins

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443937Drug ToxicityDiseaseVariantAnnotationnot associatedPD
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseVariantAnnotationnot associatedPD
PA448492asparaginaseChemicalVariantAnnotationnot associatedPD
PA449165cyclophosphamideChemicalVariantAnnotationnot associatedPD
PA449177cytarabineChemicalVariantAnnotationnot associatedPD
PA449212daunorubicinChemicalVariantAnnotationnot associatedPD
PA450379mercaptopurineChemicalVariantAnnotationnot associatedPD
PA450428methotrexateChemicalVariantAnnotationnot associatedPD
PA451100prednisoneChemicalVariantAnnotationnot associatedPD
PA451879vincristineChemicalVariantAnnotationnot associatedPD

References

Pubmed IDYearTitleCitations
199600222010E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis.76
262422662016Long noncoding RNA NEAT1 promotes glioma pathogenesis by regulating miR-449b-5p/c-Met axis.52
240867502013Small RNA profiling of influenza A virus-infected cells identifies miR-449b as a regulator of histone deacetylase 1 and interferon beta.20
311036312019MiR-449b-5p regulates cell proliferation, migration and radioresistance in cervical cancer by interacting with the transcription suppressor FOXP1.4
313508932019MicroRNA-449b-5p suppresses cell proliferation, migration and invasion by targeting TPD52 in nasopharyngeal carcinoma.3
293314132018eEF-2 Kinase-targeted miR-449b confers radiation sensitivity to cancer cells.2
314254972019MicroRNA-449b-5p Suppresses Proliferation, Migration, and Invasion of Osteosarcoma by Targeting c-Met.1
213216362011[miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line].0
236741422013miR-449b inhibits the proliferation of SW1116 colon cancer stem cells through downregulation of CCND1 and E2F3 expression.0
241209482013MicroRNAs-449a and -449b exhibit tumor suppressive effects in retinoblastoma.0

Citation

Dessen P

MIR449B (microRNA 449b)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52683/mir449b