MIR451A (microRNA 451a)

2008-10-01  

Identity

HGNC
MIR451A
LOCATION
17q11.2
LOCUSID
574411
ALIAS
MIR451,MIRN451,hsa-mir-451,hsa-mir-451a,mir-451a

Other Information

Locus ID:

NCBI: 574411
MIM: 612071
HGNC: 32053
Ensembl: ENSG00000284565
miRBase:

Variants:

dbSNP: 574411
ClinVar: 574411
TCGA: ENSG00000284565
COSMIC: MIR451A

RNA/Proteins

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

References

Pubmed IDYearTitleCitations
206993842010Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis.187
202273672010MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.165
186199462008Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells.143
213586752011MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14).117
242097502013Poly(A)-specific ribonuclease mediates 3'-end trimming of Argonaute2-cleaved precursor microRNAs.71
253622092015MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway.58
277214452016Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria.49
231468922012Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation.44
214642222011Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.43
221791242012MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma.43

Citation

Dessen P

MIR451A (microRNA 451a)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50422/mir451a