MIRLET7A3 (microRNA let-7a-3)

2007-12-01  

Identity

HGNC
LOCATION
22q13.31
LOCUSID
ALIAS
LET7A3,MIRNLET7A3,let-7a-3

Other Information

Locus ID:

NCBI: 406883
MIM: 612143
HGNC: 31478
Ensembl: ENSG00000283990
miRBase:

Variants:

dbSNP: 406883
ClinVar: 406883
TCGA: ENSG00000283990
COSMIC: MIRLET7A3

RNA/Proteins

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

References

Pubmed IDYearTitleCitations
244236092014Frequent overexpression of HMGA2 in human atypical teratoid/rhabdoid tumor and its correlation with let-7a3/let-7b miRNA.19
252473042014Protective effects of let-7a and let-7b on oxidized low-density lipoprotein induced endothelial cell injuries.19
241002392013Argonaute-3 activates the let-7a passenger strand microRNA.16
260490932015Promoter hypermethylation of let-7a-3 is relevant to its down-expression in diabetic nephropathy by targeting UHRF1.15
256470782015Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells.12
263936822015The association between let-7, RAS and HIF-1α in Ewing Sarcoma tumor growth.10
263482042015USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2.9
255159212015Overexpression of Lin28 inhibits the proliferation, migration and cell cycle progression and induces apoptosis of BGC-823 gastric cancer cells.7
247031612014MicroRNA let-7a-3 gene methylation is associated with karyotyping, CEBPA promoter methylation, and survival in acute myeloid leukemia.4
313300672019Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor.1

Citation

Dessen P

MIRLET7A3 (microRNA let-7a-3)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49877/mirlet7a3