MIRLET7D (microRNA let-7d)

2012-02-01  

Identity

HGNC
MIRLET7D
LOCATION
9q22.32
LOCUSID
406886
ALIAS
LET7D,MIRNLET7D,hsa-let-7d,let-7d

Other Information

Locus ID:

NCBI: 406886
MIM: 612145
HGNC: 31481
Ensembl: ENSG00000199133
miRBase:

Variants:

dbSNP: 406886
ClinVar: 406886
TCGA: ENSG00000199133
COSMIC: MIRLET7D

RNA/Proteins

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

References

Pubmed IDYearTitleCitations
216185192012Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1.54
204101872010Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells.32
251930152014Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7.28
263781512015miRNA let-7 expression is regulated by glucose and TNF-α by a remote upstream promoter.7
298452242018Let‑7d inhibits colorectal cancer cell proliferation through the CST1/p65 pathway.6
299759232018Let-7d Inhibits Growth and Metastasis in Breast Cancer by Targeting Jab1/Cops5.4
308164412019MicroRNA let‑7d‑5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1.3
278811572016Plasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis.2
311101762019Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis.2
318986672019Regulation of HMGA2 and KRAS genes in epithelial ovarian cancer by miRNA hsa-let-7d-3p.1

Citation

Dessen P

MIRLET7D (microRNA let-7d)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52589/mirlet7d