MIRLET7G (microRNA let-7g)

2009-04-01  

Identity

HGNC
MIRLET7G
LOCATION
3p21.2
LOCUSID
406890
ALIAS
LET7G,MIRNLET7G,hsa-let-7g,let-7g

Other Information

Locus ID:

NCBI: 406890
MIM: 612102
HGNC: 31485
Ensembl: ENSG00000199150
miRBase:

Variants:

dbSNP: 406890
ClinVar: 406890
TCGA: ENSG00000199150
COSMIC: MIRLET7G

RNA/Proteins

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

References

Pubmed IDYearTitleCitations
185505442008Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.173
191536032009Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7.150
228989842012Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).89
291748032018HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g.65
216185192012Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1.54
221579592011Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28.51
214645882011miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFκB1.36
221353612011Negative feedback regulation between microRNA let-7g and the oxLDL receptor LOX-1.32
242529102013Hsa-let-7g miRNA targets caspase-3 and inhibits the apoptosis induced by ox-LDL in endothelial cells.27
218156402011A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing.24

Citation

Dessen P

MIRLET7G (microRNA let-7g)

Atlas Genet Cytogenet Oncol Haematol. 2009-04-01

Online version: http://atlasgeneticsoncology.org/gene/50832/mirlet7g