Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 197259
MIM: 615153
HGNC: 26617
Ensembl: ENSG00000168404
Variants:
dbSNP: 197259
ClinVar: 197259
TCGA: ENSG00000168404
COSMIC: MLKL
RNA/Proteins
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37996483 | 2024 | MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis. | 3 |
| 38862702 | 2024 | MLKL regulates radiation-induced death in breast cancer cells: an interplay between apoptotic and necroptotic signals. | 0 |
| 37996483 | 2024 | MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis. | 3 |
| 38862702 | 2024 | MLKL regulates radiation-induced death in breast cancer cells: an interplay between apoptotic and necroptotic signals. | 0 |
| 34710282 | 2023 | Surviving death: emerging concepts of RIPK3 and MLKL ubiquitination in the regulation of necroptosis. | 13 |
| 35699825 | 2023 | Upregulation of necroptosis markers RIPK3/MLKL and their crosstalk with autophagy-related protein Beclin-1 in primary immune thrombocytopenia. | 0 |
| 36852999 | 2023 | MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection. | 10 |
| 37532777 | 2023 | Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells. | 3 |
| 37770424 | 2023 | A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation. | 3 |
| 37884510 | 2023 | Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization. | 0 |
| 37904209 | 2023 | MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction. | 0 |
| 38041169 | 2023 | MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease. | 2 |
| 34710282 | 2023 | Surviving death: emerging concepts of RIPK3 and MLKL ubiquitination in the regulation of necroptosis. | 13 |
| 35699825 | 2023 | Upregulation of necroptosis markers RIPK3/MLKL and their crosstalk with autophagy-related protein Beclin-1 in primary immune thrombocytopenia. | 0 |
| 36852999 | 2023 | MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection. | 10 |
Citation
Dessen P
MLKL (mixed lineage kinase domain like pseudokinase)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43362/mlkl
