MLNR (motilin receptor)

2014-11-01 Affiliation

Identity

HGNC

MLNR

LOCATION

13q14.2

LOCUSID

2862

ALIAS

GPR38,MTLR1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2862
MIM: 602885
HGNC: 4495
Ensembl: ENSG00000102539

Variants:

dbSNP: 2862
ClinVar: 2862
TCGA: ENSG00000102539
COSMIC: MLNR

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000102539	ENST00000218721	O43193

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

References

Pubmed ID	Year	Title	Citations
18183601	2008	Motilin receptor expression in smooth muscle, myenteric plexus, and mucosa of human inflamed and noninflamed intestine.	6
22465164	2012	A relationship between motilin and growth hormone secretagogue receptors.	6
16531413	2006	Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity.	4
12054506	2002	The motilin pharmacophore in CHO cells expressing the human motilin receptor.	2
18420306	2008	Desensitization and internalization of the human motilin receptor is independent of the C-terminal tail.	2
18032475	2008	Mutational analysis of predicted intracellular loop domains of human motilin receptor.	1
23142315	2013	Critical residues in the transmembrane helical bundle domains of the human motilin receptor for erythromycin binding and activity.	1
20424473	2010	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	0
30934667	2019	Effects of Motilin Receptor Agonists and Ghrelin in Human <i>motilin receptor</i> Transgenic Mice.	0

Citation

Dessen P

MLNR (motilin receptor)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70344/mlnr