Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MLST8 (MTOR associated protein, LST8 homolog)

Identity

Alias_namesMTOR associated protein, LST8 homolog (S. cerevisiae)
Alias_symbol (synonym)Lst8
Pop3
GBL
GbetaL
Other aliasLST8
POP3
WAT1
HGNC (Hugo) MLST8
LocusID (NCBI) 64223
Atlas_Id 53645
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 2205454 and ends at 2209453 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDN (12q13.12) / MLST8 (16p13.3)MLST8 (16p13.3) / FOXRED2 (22q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MLST8   24825
Cards
Entrez_Gene (NCBI)MLST8  64223  MTOR associated protein, LST8 homolog
AliasesGBL; GbetaL; LST8; POP3; 
WAT1
GeneCards (Weizmann)MLST8
Ensembl hg19 (Hinxton)ENSG00000167965 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167965 [Gene_View]  ENSG00000167965 [Sequence]  chr16:2205454-2209453 [Contig_View]  MLST8 [Vega]
ICGC DataPortalENSG00000167965
TCGA cBioPortalMLST8
AceView (NCBI)MLST8
Genatlas (Paris)MLST8
WikiGenes64223
SOURCE (Princeton)MLST8
Genetics Home Reference (NIH)MLST8
Genomic and cartography
GoldenPath hg38 (UCSC)MLST8  -     chr16:2205454-2209453 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MLST8  -     16p13.3   [Description]    (hg19-Feb_2009)
GoldenPathMLST8 - 16p13.3 [CytoView hg19]  MLST8 - 16p13.3 [CytoView hg38]
Genome Data Viewer NCBIMLST8 [Mapview hg19]  
OMIM612190   
Gene and transcription
Genbank (Entrez)AF195883 AI857555 AI933692 AK021536 AK022227
RefSeq transcript (Entrez)NM_001199173 NM_001199174 NM_001199175 NM_001352057 NM_001352059 NM_001352060 NM_022372
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MLST8
Alternative Splicing GalleryENSG00000167965
Gene ExpressionMLST8 [ NCBI-GEO ]   MLST8 [ EBI - ARRAY_EXPRESS ]   MLST8 [ SEEK ]   MLST8 [ MEM ]
Gene Expression Viewer (FireBrowse)MLST8 [ Firebrowse - Broad ]
GenevisibleExpression of MLST8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64223
GTEX Portal (Tissue expression)MLST8
Human Protein AtlasENSG00000167965-MLST8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BVC4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BVC4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BVC4
Splice isoforms : SwissVarQ9BVC4
PhosPhoSitePlusQ9BVC4
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    MLST8    Quinoprotein_ADH-like_supfam    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)MLST8
DMDM Disease mutations64223
PDB (RSDB)4JSN    4JSP    4JSV    4JSX    4JT5    4JT6    5FLC    5H64    5WBU    5WBY    5ZCS    6BCU    6BCX    6SB0    6SB2   
PDB Europe4JSN    4JSP    4JSV    4JSX    4JT5    4JT6    5FLC    5H64    5WBU    5WBY    5ZCS    6BCU    6BCX    6SB0    6SB2   
PDB (PDBSum)4JSN    4JSP    4JSV    4JSX    4JT5    4JT6    5FLC    5H64    5WBU    5WBY    5ZCS    6BCU    6BCX    6SB0    6SB2   
PDB (IMB)4JSN    4JSP    4JSV    4JSX    4JT5    4JT6    5FLC    5H64    5WBU    5WBY    5ZCS    6BCU    6BCX    6SB0    6SB2   
Structural Biology KnowledgeBase4JSN    4JSP    4JSV    4JSX    4JT5    4JT6    5FLC    5H64    5WBU    5WBY    5ZCS    6BCU    6BCX    6SB0    6SB2   
SCOP (Structural Classification of Proteins)4JSN    4JSP    4JSV    4JSX    4JT5    4JT6    5FLC    5H64    5WBU    5WBY    5ZCS    6BCU    6BCX    6SB0    6SB2   
CATH (Classification of proteins structures)4JSN    4JSP    4JSV    4JSX    4JT5    4JT6    5FLC    5H64    5WBU    5WBY    5ZCS    6BCU    6BCX    6SB0    6SB2   
SuperfamilyQ9BVC4
Human Protein Atlas [tissue]ENSG00000167965-MLST8 [tissue]
Peptide AtlasQ9BVC4
HPRD17031
IPIIPI00102926   IPI00420058   IPI00007182   IPI00908527   IPI00657689   
Protein Interaction databases
DIP (DOE-UCLA)Q9BVC4
IntAct (EBI)Q9BVC4
FunCoupENSG00000167965
BioGRIDMLST8
STRING (EMBL)MLST8
ZODIACMLST8
Ontologies - Pathways
QuickGOQ9BVC4
Ontology : AmiGOprotein binding  nucleoplasm  cytoplasm  cytosol  cell cycle arrest  regulation of macroautophagy  positive regulation of actin filament polymerization  TOR signaling  TORC1 complex  TORC1 complex  TORC2 complex  TORC2 complex  positive regulation of TOR signaling  activation of protein kinase B activity  regulation of actin cytoskeleton organization  regulation of actin cytoskeleton organization  TORC1 signaling  regulation of GTPase activity  protein serine/threonine kinase activator activity  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of protein serine/threonine kinase activity  regulation of cellular response to heat  
Ontology : EGO-EBIprotein binding  nucleoplasm  cytoplasm  cytosol  cell cycle arrest  regulation of macroautophagy  positive regulation of actin filament polymerization  TOR signaling  TORC1 complex  TORC1 complex  TORC2 complex  TORC2 complex  positive regulation of TOR signaling  activation of protein kinase B activity  regulation of actin cytoskeleton organization  regulation of actin cytoskeleton organization  TORC1 signaling  regulation of GTPase activity  protein serine/threonine kinase activator activity  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of protein serine/threonine kinase activity  regulation of cellular response to heat  
Pathways : KEGGmTOR signaling pathway    PI3K-Akt signaling pathway   
NDEx NetworkMLST8
Atlas of Cancer Signalling NetworkMLST8
Wikipedia pathwaysMLST8
Orthology - Evolution
OrthoDB64223
GeneTree (enSembl)ENSG00000167965
Phylogenetic Trees/Animal Genes : TreeFamMLST8
HOGENOMQ9BVC4
Homologs : HomoloGeneMLST8
Homology/Alignments : Family Browser (UCSC)MLST8
Gene fusions - Rearrangements
Fusion : QuiverMLST8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMLST8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MLST8
dbVarMLST8
ClinVarMLST8
1000_GenomesMLST8 
Exome Variant ServerMLST8
GNOMAD BrowserENSG00000167965
Varsome BrowserMLST8
Genetic variants : HAPMAP64223
Genomic Variants (DGV)MLST8 [DGVbeta]
DECIPHERMLST8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMLST8 
Mutations
ICGC Data PortalMLST8 
TCGA Data PortalMLST8 
Broad Tumor PortalMLST8
OASIS PortalMLST8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMLST8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMLST8
Mutations and Diseases : HGMDMLST8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect MLST8
DgiDB (Drug Gene Interaction Database)MLST8
DoCM (Curated mutations)MLST8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MLST8 (select a term)
intoGenMLST8
Cancer3DMLST8 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612190   
Orphanet
DisGeNETMLST8
MedgenMLST8
Genetic Testing Registry MLST8
NextProtQ9BVC4 [Medical]
TSGene64223
GENETestsMLST8
Open Targets GeneticsENSG00000167965  [validation]
snp3D : Map Gene to Disease64223
BioCentury BCIQMLST8
ClinGenMLST8
Clinical trials, drugs, therapy
Protein Interactions : CTD64223
Pharm GKB GenePA165450213
Clinical trialMLST8
Miscellaneous
canSAR (ICR)MLST8 (select the gene name)
HarmonizomeMLST8
DataMed IndexMLST8
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMLST8
EVEXMLST8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 20:00:27 CEST 2020
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