MLX (MAX dimerization protein MLX)

2001-01-01  

Identity

HGNC
MLX
LOCATION
17q21.2
LOCUSID
6945
ALIAS
MAD7,MXD7,TCFL4,TF4,bHLHd13
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6945
MIM: 602976
HGNC: 11645
Ensembl: ENSG00000108788

Variants:

dbSNP: 6945
ClinVar: 6945
TCGA: ENSG00000108788
COSMIC: MLX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108788ENST00000246912Q9UH92
ENSG00000108788ENST00000346833Q9UH92
ENSG00000108788ENST00000435881Q9UH92
ENSG00000108788ENST00000591024K7EID0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
ChREBP activates metabolic gene expressionREACTOMER-HSA-163765
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
184583402008Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.101
256404022015Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.62
156649962005Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.56
167828752006MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis.51
248577472015Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.38
124467712002A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex.23
303542982018Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis.0

Citation

Dessen P

MLX (MAX dimerization protein MLX)

Atlas Genet Cytogenet Oncol Haematol. 2001-01-01

Online version: http://atlasgeneticsoncology.org/gene/78577/mlx