Identity
HGNC
LOCATION
7q11.23
LOCUSID
ALIAS
CHREBP,MIO,MLX,MONDOB,WBSCR14,WS-bHLH,bHLHd14
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51085
MIM: 605678
HGNC: 12744
Ensembl: ENSG00000009950
Variants:
dbSNP: 51085
ClinVar: 51085
TCGA: ENSG00000009950
COSMIC: MLXIPL
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA33744 | PRKAA1 | Gene | Pathway | associated | 22722338 | ||
| PA33745 | PRKAA2 | Gene | Pathway | associated | 22722338 | ||
| PA33746 | PRKAB1 | Gene | Pathway | associated | 22722338 | ||
| PA33747 | PRKAB2 | Gene | Pathway | associated | 22722338 | ||
| PA33751 | PRKAG1 | Gene | Pathway | associated | 22722338 | ||
| PA33752 | PRKAG2 | Gene | Pathway | associated | 22722338 | ||
| PA33753 | PRKAG3 | Gene | Pathway | associated | 22722338 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38101397 | 2024 | ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits. | 2 |
| 38128383 | 2024 | Knockdown of ChREBP ameliorates retinal microvascular endothelial cell injury and angiogenic responses in diabetic retinopathy. | 0 |
| 38331848 | 2024 | Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity. | 1 |
| 38668731 | 2024 | A genome-first approach to variants in MLXIPL and their association with hepatic steatosis and plasma lipids. | 1 |
| 38101397 | 2024 | ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits. | 2 |
| 38128383 | 2024 | Knockdown of ChREBP ameliorates retinal microvascular endothelial cell injury and angiogenic responses in diabetic retinopathy. | 0 |
| 38331848 | 2024 | Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity. | 1 |
| 38668731 | 2024 | A genome-first approach to variants in MLXIPL and their association with hepatic steatosis and plasma lipids. | 1 |
| 36413406 | 2023 | HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis. | 5 |
| 36809979 | 2023 | MLXIPL promotes the migration, invasion, and glycolysis of hepatocellular carcinoma cells by phosphorylation of mTOR. | 4 |
| 36923222 | 2023 | New insights into the inter-organ crosstalk mediated by ChREBP. | 1 |
| 37055547 | 2023 | The role of ChREBP in carbohydrate sensing and NAFLD development. | 15 |
| 36413406 | 2023 | HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis. | 5 |
| 36809979 | 2023 | MLXIPL promotes the migration, invasion, and glycolysis of hepatocellular carcinoma cells by phosphorylation of mTOR. | 4 |
| 36923222 | 2023 | New insights into the inter-organ crosstalk mediated by ChREBP. | 1 |
Citation
Dessen P
MLXIPL (MLX interacting protein like)
Atlas Genet Cytogenet Oncol Haematol. 2010-02-01
Online version: http://atlasgeneticsoncology.org/gene/51326/mlxipl
