MMP12 (matrix metallopeptidase 12)

2003-02-01  

Identity

HGNC
LOCATION
11q22.2
LOCUSID
ALIAS
HME,ME,MME,MMP-12
FUSION GENES

Other Information

Locus ID:

NCBI: 4321
MIM: 601046
HGNC: 7158
Ensembl: ENSG00000262406

Variants:

dbSNP: 4321
ClinVar: 4321
TCGA: ENSG00000262406
COSMIC: MMP12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000262406ENST00000571244P39900

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Collagen degradationREACTOMER-HSA-1442490

References

Pubmed IDYearTitleCitations
200189592009MMP12, lung function, and COPD in high-risk populations.107
200189592009MMP12, lung function, and COPD in high-risk populations.107
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
161666182005A distinctive alveolar macrophage activation state induced by cigarette smoking.81
186603812008Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx.77
219208922012Series "matrix metalloproteinases in lung health and disease": Matrix metalloproteinases in COPD.73
247842322014A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity.72
118750512002The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function.70
118750512002The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function.70
157232022005Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease.58

Citation

Dessen P

MMP12 (matrix metallopeptidase 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41389/mmp12