MMP17 (matrix metallopeptidase 17)

2003-06-01  

Identity

HGNC
LOCATION
12q24.33
LOCUSID
ALIAS
MMP-17,MT4-MMP,MT4MMP,MTMMP4

Other Information

Locus ID:

NCBI: 4326
MIM: 602285
HGNC: 7163
Ensembl: ENSG00000198598

Variants:

dbSNP: 4326
ClinVar: 4326
TCGA: ENSG00000198598
COSMIC: MMP17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198598ENST00000360564Q9ULZ9
ENSG00000198598ENST00000534865F5H881
ENSG00000198598ENST00000535004F5H209
ENSG00000198598ENST00000535291Q9ULZ9
ENSG00000198598ENST00000537848F5H846
ENSG00000198598ENST00000542648F5H249
ENSG00000198598ENST00000545671F5GZA7
ENSG00000198598ENST00000545790F5GWR3

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389

References

Pubmed IDYearTitleCitations
147018642004ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.58
200198452009Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis.37
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
204524822010Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.26
259637162015Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice.15
194261562009Membrane-type 4 matrix metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture.13
226748542013Restoration of caveolin-1 expression suppresses growth, membrane-type-4 metalloproteinase expression and metastasis-associated activities in colon cancer cells.13
129627062003Expression of membrane type-4 matrix metalloproteinase (metalloproteinase-17) by human eosinophils.11
253200132014EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP.9
218280522011Characterization of the dimerization interface of membrane type 4 (MT4)-matrix metalloproteinase.8

Citation

Dessen P

MMP17 (matrix metallopeptidase 17)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41394/mmp17