Identity
HGNC
LOCATION
11q22.2
LOCUSID
ALIAS
CHDS6,MMP-3,SL-1,STMY,STMY1,STR1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4314
MIM: 185250
HGNC: 7173
Ensembl: ENSG00000149968
Variants:
dbSNP: 4314
ClinVar: 4314
TCGA: ENSG00000149968
COSMIC: MMP3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000149968 | ENST00000299855 | P08254 |
| ENSG00000149968 | ENST00000434103 | H7C139 |
| ENSG00000149968 | ENST00000524478 | E9PKX2 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443796 | Coronary Artery Disease | Disease | ClinicalAnnotation | associated | PD | 10190398 | |
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | ||
| PA448970 | chlorthalidone | Chemical | ClinicalAnnotation | associated | PD | ||
| PA450242 | lisinopril | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451089 | pravastatin | Chemical | ClinicalAnnotation | associated | PD | 10190398 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37442641 | 2024 | MMP3 single-nucleotide polymorphisms are associated with noncontact ACL injuries in competing high-level athletes. | 0 |
| 38454645 | 2024 | Smooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification. | 1 |
| 39000435 | 2024 | Growth Differentiation Factor 15 and Matrix Metalloproteinase 3 in Plasma as Biomarkers for Neuropathy and Nephropathy in Type 1 Diabetes. | 0 |
| 37442641 | 2024 | MMP3 single-nucleotide polymorphisms are associated with noncontact ACL injuries in competing high-level athletes. | 0 |
| 38454645 | 2024 | Smooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification. | 1 |
| 39000435 | 2024 | Growth Differentiation Factor 15 and Matrix Metalloproteinase 3 in Plasma as Biomarkers for Neuropathy and Nephropathy in Type 1 Diabetes. | 0 |
| 34860335 | 2023 | Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses for Platelet Reactivity and Clinical Outcomes of Repeat Revascularization After First PCI in Chinese Patients. | 0 |
| 36319784 | 2023 | Association of the matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of coronavirus disease 2019 (COVID-19); implications of contribution for development of neurological symptoms in the COVID-19 patients. | 4 |
| 36640492 | 2023 | Over-expression of USP15/MMP3 predict poor prognosis and promote growth, migration in non-small cell lung cancer cells. | 4 |
| 36739977 | 2023 | Comparative evaluation of the trabecular structure of the mandibular condyle, the levels of salivary cortisol, MMP-3, TNF-α, IL-1β in individuals with and without temporomandibular joint disorder. | 0 |
| 36808352 | 2023 | The promoter methylations of the autoimmune regulator (AIRE) gene and matrix metalloproteinase-3 (MMP-3) gene may have a role in gestational diabetes mellitus. | 0 |
| 37176106 | 2023 | The Transcriptomic Profiles of ESR1 and MMP3 Stratify the Risk of Biochemical Recurrence in Primary Prostate Cancer beyond Clinical Features. | 4 |
| 37471217 | 2023 | Association of MMP3 gene polymorphism and sex on recovery of muscle strength after eccentric exercise. | 0 |
| 37551683 | 2023 | MMP-3 -1171 5A/6A promoter polymorphism and cancer susceptibility: an updated meta-analysis and trial sequential analysis. | 0 |
| 37986083 | 2023 | Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study. | 0 |
Citation
Dessen P
MMP3 (matrix metallopeptidase 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41406/mmp3
