MOB4 (MOB family member 4, phocein)

2014-10-01  

Identity

HGNC
LOCATION
2q33.1
LOCUSID
ALIAS
2C4D,CGI-95,MOB1,MOB3,MOBKL3,PHOCN,PREI3
FUSION GENES

Other Information

Locus ID:

NCBI: 25843
MIM: 609361
HGNC: 17261
Ensembl: ENSG00000115540

Variants:

dbSNP: 25843
ClinVar: 25843
TCGA: ENSG00000115540
COSMIC: MOB4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115540ENST00000233892Q9Y3A3
ENSG00000115540ENST00000323303Q9Y3A3
ENSG00000115540ENST00000323303A0A024R3X9
ENSG00000115540ENST00000409355F8W8B0
ENSG00000115540ENST00000409360Q9Y3A3
ENSG00000115540ENST00000409916B4DM50
ENSG00000115540ENST00000417097F8WAQ8
ENSG00000115540ENST00000448447Q9Y3A3

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183628902008Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.24
300723782018The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.12
248723892014hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.7

Citation

Dessen P

MOB4 (MOB family member 4, phocein)

Atlas Genet Cytogenet Oncol Haematol. 2014-10-01

Online version: http://atlasgeneticsoncology.org/gene/54904/mob4