MOG (myelin oligodendrocyte glycoprotein)

2016-10-01  

Identity

HGNC
MOG
LOCATION
6p22.1
LOCUSID
4340
ALIAS
BTN6,BTNL11,MOGIG2,NRCLP7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4340
MIM: 159465
HGNC: 7197
Ensembl: ENSG00000204655

Variants:

dbSNP: 4340
ClinVar: 4340
TCGA: ENSG00000204655
COSMIC: MOG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204655ENST00000376888Q16653
ENSG00000204655ENST00000376889H0Y8A0
ENSG00000204655ENST00000376891Q16653
ENSG00000204655ENST00000376894Q16653
ENSG00000204655ENST00000376898Q16653
ENSG00000204655ENST00000376903H7BYC0
ENSG00000204655ENST00000376917Q16653
ENSG00000204655ENST00000396701Q16653
ENSG00000204655ENST00000396704Q16653
ENSG00000204655ENST00000416766C9JTE0
ENSG00000204655ENST00000431798Q16653
ENSG00000204655ENST00000483013E9PG44
ENSG00000204655ENST00000485211H0Y8A0
ENSG00000204655ENST00000490427Q16653
ENSG00000204655ENST00000494692Q16653

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
244155682014Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders.154
222046622011Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders.102
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
217956512011Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis.79
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
171423212006Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis.60
196870982009Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis.60
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
128170312003Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice.54
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51

Citation

Dessen P

MOG (myelin oligodendrocyte glycoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56532/mog