MORC2 (MORC family CW-type zinc finger 2)

2011-11-01  

Identity

HGNC
LOCATION
22q12.2
LOCUSID
ALIAS
CMT2Z,DIGFAN,ZCW3,ZCWCC1

Other Information

Locus ID:

NCBI: 22880
MIM: 616661
HGNC: 23573
Ensembl: ENSG00000133422

Variants:

dbSNP: 22880
ClinVar: 22880
TCGA: ENSG00000133422
COSMIC: MORC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133422ENST00000215862Q9Y6X9
ENSG00000133422ENST00000397641Q9Y6X9
ENSG00000133422ENST00000429468H7C3M1
ENSG00000133422ENST00000445980H7C1V1

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232606672012MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response.37
285815002017Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.21
242868642014Cytosolic functions of MORC2 in lipogenesis and adipogenesis.15
264979052016Mutations in the MORC2 gene cause axonal Charcot-Marie-Tooth disease.14
300935602018Cancer-Associated MORC2-Mutant M276I Regulates an hnRNPM-Mediated CD44 Splicing Switch to Promote Invasion and Metastasis in Triple-Negative Breast Cancer.14
260987742015By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.13
258886272015PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis.11
202252022010Identification and expression analysis of a novel CW-type zinc finger protein MORC2 in cancer cells.9
264762142015Microchidia protein 2, MORC2, downregulates the cytoskeleton adapter protein, ArgBP2, via histone methylation in gastric cancer cells.9
266598482016MORC2 mutations cause axonal Charcot-Marie-Tooth disease with pyramidal signs.9

Citation

Dessen P

MORC2 (MORC family CW-type zinc finger 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-11-01

Online version: http://atlasgeneticsoncology.org/gene/52474/morc2