Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 22880
MIM: 616661
HGNC: 23573
Ensembl: ENSG00000133422
Variants:
dbSNP: 22880
ClinVar: 22880
TCGA: ENSG00000133422
COSMIC: MORC2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000133422 | ENST00000215862 | Q9Y6X9 |
| ENSG00000133422 | ENST00000397641 | Q9Y6X9 |
| ENSG00000133422 | ENST00000429468 | H7C3M1 |
| ENSG00000133422 | ENST00000445980 | H7C1V1 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38227798 | 2024 | Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase. | 1 |
| 38227798 | 2024 | Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase. | 1 |
| 36802305 | 2023 | MORC2 and MAX contributes to the expression of glycolytic enzymes, breast cancer cell proliferation and migration. | 3 |
| 36967563 | 2023 | Destabilization of microrchidia family CW-type zinc finger 2 via the cyclin-dependent kinase 1-chaperone-mediated autophagy pathway promotes mitotic arrest and enhances cancer cellular sensitivity to microtubule-targeting agents. | 2 |
| 37737260 | 2023 | Alternative polyadenylation reprogramming of MORC2 induced by NUDT21 loss promotes KIRC carcinogenesis. | 1 |
| 37892209 | 2023 | Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer. | 0 |
| 36802305 | 2023 | MORC2 and MAX contributes to the expression of glycolytic enzymes, breast cancer cell proliferation and migration. | 3 |
| 36967563 | 2023 | Destabilization of microrchidia family CW-type zinc finger 2 via the cyclin-dependent kinase 1-chaperone-mediated autophagy pathway promotes mitotic arrest and enhances cancer cellular sensitivity to microtubule-targeting agents. | 2 |
| 37737260 | 2023 | Alternative polyadenylation reprogramming of MORC2 induced by NUDT21 loss promotes KIRC carcinogenesis. | 1 |
| 37892209 | 2023 | Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer. | 0 |
| 34913078 | 2022 | Microrchidia family CW‑type zinc finger 2 promotes the proliferation, invasion, migration and epithelial‑mesenchymal transition of glioma by regulating PTEN/PI3K/AKT signaling via binding to N‑myc downstream regulated gene 1 promoter. | 5 |
| 35522895 | 2022 | HSP90 N-terminal inhibitors target oncoprotein MORC2 for autophagic degradation and suppress MORC2-driven breast cancer progression. | 7 |
| 35904125 | 2022 | Expanding the phenotypic variability of MORC2 gene mutations: From Charcot-Marie-Tooth disease to late-onset pure motor neuropathy. | 6 |
| 35920923 | 2022 | A Cockayne-like phenotype resulting from a de novo variant in MORC2: expanding the phenotype of MORC2-related disorders. | 4 |
| 34913078 | 2022 | Microrchidia family CW‑type zinc finger 2 promotes the proliferation, invasion, migration and epithelial‑mesenchymal transition of glioma by regulating PTEN/PI3K/AKT signaling via binding to N‑myc downstream regulated gene 1 promoter. | 5 |
Citation
Dessen P
MORC2 (MORC family CW-type zinc finger 2)
Atlas Genet Cytogenet Oncol Haematol. 2011-11-01
Online version: http://atlasgeneticsoncology.org/gene/52474/morc2
