MPC1 (mitochondrial pyruvate carrier 1)

2015-03-01  

Identity

HGNC
LOCATION
6q27
LOCUSID
ALIAS
BRP44L,CGI-129,MPYCD,SLC54A1

Other Information

Locus ID:

NCBI: 51660
MIM: 614738
HGNC: 21606
Ensembl: ENSG00000060762

Variants:

dbSNP: 51660
ClinVar: 51660
TCGA: ENSG00000060762
COSMIC: MPC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000060762ENST00000341756Q5TI65
ENSG00000060762ENST00000360961Q9Y5U8
ENSG00000060762ENST00000621630A0A087WVZ0
ENSG00000060762ENST00000621685Q5TI65

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
226285582012A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.226
254588412014A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.104
198345352009Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.27
268951002016MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer.21
176729182007Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.17
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
266420432015Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier.10
283976872017A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).9
308087462019Loss of MPC1 reprograms retinal metabolism to impair visual function.9
294725612018Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter.7

Citation

Dessen P

MPC1 (mitochondrial pyruvate carrier 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55114/mpc1