MPC2 (mitochondrial pyruvate carrier 2)

2015-03-01  

Identity

HGNC
LOCATION
1q24.2
LOCUSID
ALIAS
BRP44,SLC54A2
FUSION GENES

Other Information

Locus ID:

NCBI: 25874
MIM: 614737
HGNC: 24515
Ensembl: ENSG00000143158

Variants:

dbSNP: 25874
ClinVar: 25874
TCGA: ENSG00000143158
COSMIC: MPC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143158ENST00000271373O95563
ENSG00000143158ENST00000271373A0A024R8Z5
ENSG00000143158ENST00000367846O95563
ENSG00000143158ENST00000367846A0A024R8Z5
ENSG00000143158ENST00000458574Q5R3B4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
254588412014A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.104
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.30
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
190646102009Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.16
265774102015Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity.15
278522612016MPC1 and MPC2 expressions are associated with favorable clinical outcomes in prostate cancer.10
294725612018Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter.7
30221281986Structural characterization of a heterogeneous family of rat brain mRNAs.4
239331552013Lack of association between MPC2 variants and schizophrenia in a replication study of Han Chinese.3
303560332018C-Terminal Binding Protein 1 Modulates Cellular Redox via Feedback Regulation of MPC1 and MPC2 in Melanoma Cells.3

Citation

Dessen P

MPC2 (mitochondrial pyruvate carrier 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55100/mpc2