MPG (N-methylpurine DNA glycosylase)

2003-02-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
AAG,ADPG,APNG,CRA36.1,MDG,Mid1,PIG11,PIG16,anpg
FUSION GENES

Other Information

Locus ID:

NCBI: 4350
MIM: 156565
HGNC: 7211
Ensembl: ENSG00000103152

Variants:

dbSNP: 4350
ClinVar: 4350
TCGA: ENSG00000103152
COSMIC: MPG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103152ENST00000219431P29372
ENSG00000103152ENST00000219431Q1W6H1
ENSG00000103152ENST00000356432P29372
ENSG00000103152ENST00000397817P29372
ENSG00000103152ENST00000436333A2IDA3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Base excision repairKEGGhsa03410
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Base-Excision Repair, AP Site FormationREACTOMER-HSA-73929
DepurinationREACTOMER-HSA-73927
Recognition and association of DNA glycosylase with site containing an affected purineREACTOMER-HSA-110330
Cleavage of the damaged purineREACTOMER-HSA-110331
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Displacement of DNA glycosylase by APEX1REACTOMER-HSA-110357

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
161952372006Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.112
80160811994Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases.78
146882482004Dissecting the broad substrate specificity of human 3-methyladenine-DNA glycosylase.72
221561952012Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.50
145677032003Human alkyladenine DNA glycosylase uses acid-base catalysis for selective excision of damaged purines.47
192199892009Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG).45
188399662008Human alkyladenine DNA glycosylase employs a processive search for DNA damage.39
1201620620021,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase.33
152472092004Oxanine DNA glycosylase activity from Mammalian alkyladenine glycosylase.30
202015992010Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein.30

Citation

Dessen P

MPG (N-methylpurine DNA glycosylase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41418/mpg