MPHOSPH8 (M-phase phosphoprotein 8)

2010-12-01  

Identity

HGNC
MPHOSPH8
LOCATION
13q12.11
LOCUSID
54737
ALIAS
HSMPP8,TWA3,mpp8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54737
MIM: 611626
HGNC: 29810
Ensembl: ENSG00000196199

Variants:

dbSNP: 54737
ClinVar: 54737
TCGA: ENSG00000196199
COSMIC: MPHOSPH8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196199ENST00000361479Q99549
ENSG00000196199ENST00000414242A0A0A0MT47
ENSG00000196199ENST00000449056H0Y6J1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
335967862021MPP8 Promotes Proliferation and Restrains Apoptosis in Osteosarcoma by Regulating p38αMAPK Pathway.0
335967862021MPP8 Promotes Proliferation and Restrains Apoptosis in Osteosarcoma by Regulating p38αMAPK Pathway.0
316920322020M-phase phosphoprotein 8 promotes gastric cancer growth and metastasis via p53/Bcl-2 and EMT-related signaling pathways.6
316920322020M-phase phosphoprotein 8 promotes gastric cancer growth and metastasis via p53/Bcl-2 and EMT-related signaling pathways.6
294127902018Knockdown of MPP8 suppresses cell proliferation via regulation of HOXA5 in non-small cell lung cancer cells.5
294127902018Knockdown of MPP8 suppresses cell proliferation via regulation of HOXA5 in non-small cell lung cancer cells.5
268535312016Position-effect variegation revisited: HUSHing up heterochromatin in human cells.20
268535312016Position-effect variegation revisited: HUSHing up heterochromatin in human cells.20
256604502015Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis.6
258702362015MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition.32
260224162015GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.163
256604502015Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis.6
258702362015MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition.32
260224162015GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.163
234160732013Mitotic phosphorylation of MPP8 by cyclin-dependent kinases regulates chromatin dissociation.4

Citation

Dessen P

MPHOSPH8 (M-phase phosphoprotein 8)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51839/mphosph8