MPHOSPH8 (M-phase phosphoprotein 8)

2010-12-01  

Identity

HGNC
LOCATION
13q12.11
LOCUSID
ALIAS
HSMPP8,TWA3,mpp8
FUSION GENES

Other Information

Locus ID:

NCBI: 54737
MIM: 611626
HGNC: 29810
Ensembl: ENSG00000196199

Variants:

dbSNP: 54737
ClinVar: 54737
TCGA: ENSG00000196199
COSMIC: MPHOSPH8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196199ENST00000361479Q99549
ENSG00000196199ENST00000414242A0A0A0MT47
ENSG00000196199ENST00000449056H0Y6J1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
260224162015GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.58
208715922010Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion.55
214191342011Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding.25
220223772011Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.16
258702362015MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition.15
268535312016Position-effect variegation revisited: HUSHing up heterochromatin in human cells.6
256604502015Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis.3
234160732013Mitotic phosphorylation of MPP8 by cyclin-dependent kinases regulates chromatin dissociation.2
235328742013Humanin binds MPP8: mapping interaction sites of the peptide and protein.2
294127902018Knockdown of MPP8 suppresses cell proliferation via regulation of HOXA5 in non-small cell lung cancer cells.0

Citation

Dessen P

MPHOSPH8 (M-phase phosphoprotein 8)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51839/mphosph8