MPZL1 (myelin protein zero like 1)

2014-10-01  

Identity

HGNC
MPZL1
LOCATION
1q24.2
LOCUSID
9019
ALIAS
MPZL1b,PZR,PZR1b,PZRa,PZRb
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9019
MIM: 604376
HGNC: 7226
Ensembl: ENSG00000197965

Variants:

dbSNP: 9019
ClinVar: 9019
TCGA: ENSG00000197965
COSMIC: MPZL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197965ENST00000359523O95297
ENSG00000197965ENST00000359523A8K5D4
ENSG00000197965ENST00000367853Q9UEL6
ENSG00000197965ENST00000392121O95297
ENSG00000197965ENST00000448405F8WFC4
ENSG00000197965ENST00000474859O95297
ENSG00000197965ENST00000474859A0A024R8Y3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.30
242967792014Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma.26
190646102009Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.16
117519242002Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling.14
185689532008Phosphorylation and localization of protein-zero related (PZR) in cultured endothelial cells.10
126840382003Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs.4
167029742006MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese.4
167029742006MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese.4
196295672009Charcot–Marie–Tooth disease type 2J with MPZ Thr124Met mutation: clinico-electrophysiological and MRI study of a family.4

Citation

Dessen P

MPZL1 (myelin protein zero like 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-10-01

Online version: http://atlasgeneticsoncology.org/gene/54902/mpzl1