MR1 (major histocompatibility complex, class I-related)

2009-11-01  

Identity

HGNC
MR1
LOCATION
1q25.3
LOCUSID
3140
ALIAS
HLALS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3140
MIM: 600764
HGNC: 4975
Ensembl: ENSG00000153029

Variants:

dbSNP: 3140
ClinVar: 3140
TCGA: ENSG00000153029
COSMIC: MR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153029ENST00000282990Q95460
ENSG00000153029ENST00000367579Q95460
ENSG00000153029ENST00000367580Q95460
ENSG00000153029ENST00000434571Q95460
ENSG00000153029ENST00000614012Q95460
ENSG00000153029ENST00000617803Q95460

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
230517532012MR1 presents microbial vitamin B metabolites to MAIT cells.332
241013822013Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells.170
211907362011The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice.74
250493332014MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage.74
224121572012Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor.67
194168702009MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution.66
226924542013Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress.57
263883322015Lipid and small-molecule display by CD1 and MR1.48
245563962014MAITs, MR1 and vitamin B metabolites.39
257529002015High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells.39

Citation

Dessen P

MR1 (major histocompatibility complex, class I-related)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51228/mr1