MRAP2 (melanocortin 2 receptor accessory protein 2)

2014-11-01  

Identity

HGNC
MRAP2
LOCATION
6q14.2
LOCUSID
112609
ALIAS
C6orf117,bA51G5.2

Other Information

Locus ID:

NCBI: 112609
MIM: 615410
HGNC: 21232
Ensembl: ENSG00000135324

Variants:

dbSNP: 112609
ClinVar: 112609
TCGA: ENSG00000135324
COSMIC: MRAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135324ENST00000257776Q96G30

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
193294862009MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.53
238690162013Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity.44
203717712010Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2.16
213679682011Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland.16
234183612013Melanocortin receptor accessory proteins in adrenal gland physiology and beyond.10
224197222012Melanocortin 2 receptor-associated protein (MRAP) and MRAP2 in human adrenocortical tissues: regulation of expression and association with ACTH responsiveness.9
284999892017Melanocortin Receptor Accessory Proteins (MRAPs): Functions in the melanocortin system and beyond.8
289390582017Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling.8
274748722016Decreased melanocortin-4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene.6
250511712014Melanocortin 3 receptor has a 5' exon that directs translation of apically localized protein from the second in-frame ATG.4

Citation

Dessen P

MRAP2 (melanocortin 2 receptor accessory protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70405/mrap2