MRGPRX2 (MAS related GPR family member X2)

2013-11-01  

Identity

HGNC
LOCATION
11p15.1
LOCUSID
ALIAS
MGRG3,MRGX2

Other Information

Locus ID:

NCBI: 117194
MIM: 607228
HGNC: 17983
Ensembl: ENSG00000183695

Variants:

dbSNP: 117194
ClinVar: 117194
TCGA: ENSG00000183695
COSMIC: MRGPRX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183695ENST00000329773Q96LB1

Expression (GTEx)

0
1
2

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220693232011Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization.52
249542762014Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria.44
129154022003MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.43
236987492013β-Defensins activate human mast cells via Mas-related gene X2.27
186363142008Angiotensin metabolites can stimulate receptors of the Mas-related genes family.23
300727292018MRGPRX2-mediated mast cell response to drugs used in perioperative procedures and anaesthesia.9
286942912017Differential Regulation of Mas-Related G Protein-Coupled Receptor X2-Mediated Mast Cell Degranulation by Antimicrobial Host Defense Peptides and Porphyromonas gingivalis Lipopolysaccharide.8
288592482018Allergic FcεRI- and pseudo-allergic MRGPRX2-triggered mast cell activation routes are independent and inversely regulated by SCF.8
292957032018Upregulation of Mas-related G Protein coupled receptor X2 in asthmatic lung mast cells and its activation by the novel neuropeptide hemokinin-1.8
158622862005Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception.5

Citation

Dessen P

MRGPRX2 (MAS related GPR family member X2)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53587/mrgprx2