MRPL58 (mitochondrial ribosomal protein L58)

2017-10-01  

Identity

HGNC
MRPL58
LOCATION
17q25.1
LOCUSID
3396
ALIAS
DS-1,DS1,ICT1,MRP-L58

Other Information

Locus ID:

NCBI: 3396
MIM: 603000
HGNC: 5359
Ensembl: ENSG00000167862

Variants:

dbSNP: 3396
ClinVar: 3396
TCGA: ENSG00000167862
COSMIC: MRPL58

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167862ENST00000301585Q14197
ENSG00000167862ENST00000580800J3QRF8
ENSG00000167862ENST00000584208J3KS15

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial translationREACTOMER-HSA-5368287
Mitochondrial translation initiationREACTOMER-HSA-5368286
Mitochondrial translation elongationREACTOMER-HSA-5389840
Mitochondrial translation terminationREACTOMER-HSA-5419276

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
201861202010A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome.57
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
288264872017A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes.5
289879422017miR-205 regulation of ICT1 has an oncogenic potential via promoting the migration and invasion of gastric cancer cells.5
299518812018MiR-1301-3p inhibits human breast cancer cell proliferation by regulating cell cycle progression and apoptosis through directly targeting ICT1.3
274115512016Immature Colon Carcinoma Transcript-1 (ICT1) Expression Correlates with Unfavorable Prognosis and Survival in Patients with Colorectal Cancer.2
286298252017ICT1 predicts a poor survival and correlated with cell proliferation in diffuse large B-cell lymphoma.2
282906012017ICT1 knockdown inhibits breast cancer cell growth via induction of cell cycle arrest and apoptosis.1
274131662017Knockdown of Immature Colon Carcinoma Transcript 1 Inhibits Proliferation and Promotes Apoptosis of Non-Small Cell Lung Cancer Cells.0
290362642017Immature colon carcinoma transcript-1 promotes proliferation of gastric cancer cells.0

Citation

Dessen P

MRPL58 (mitochondrial ribosomal protein L58)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57170/mrpl58