Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57380
HGNC: 13785
Ensembl: ENSG00000124532
Variants:
dbSNP: 57380
ClinVar: 57380
TCGA: ENSG00000124532
COSMIC: MRS2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transmembrane transport of small molecules | REACTOME | R-HSA-382551 |
| Miscellaneous transport and binding events | REACTOME | R-HSA-5223345 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38599304 | 2024 | Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca(2+) uptake and viability. | 1 |
| 38599304 | 2024 | Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca(2+) uptake and viability. | 1 |
| 36754568 | 2023 | The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity. | 6 |
| 37543649 | 2023 | Molecular basis of Mg(2+) permeation through the human mitochondrial Mrs2 channel. | 8 |
| 37938562 | 2023 | Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms. | 3 |
| 36754568 | 2023 | The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity. | 6 |
| 37543649 | 2023 | Molecular basis of Mg(2+) permeation through the human mitochondrial Mrs2 channel. | 8 |
| 37938562 | 2023 | Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms. | 3 |
| 27458051 | 2016 | Mitochondrial Mg(2+) homeostasis decides cellular energy metabolism and vulnerability to stress. | 66 |
| 27458051 | 2016 | Mitochondrial Mg(2+) homeostasis decides cellular energy metabolism and vulnerability to stress. | 66 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 18384665 | 2009 | Conditional knockdown of hMRS2 results in loss of mitochondrial Mg(2+) uptake and cell death. | 30 |
| 19242098 | 2009 | Human mitochondrial Mrs2 protein promotes multidrug resistance in gastric cancer cells by regulating p27, cyclin D1 expression and cytochrome C release. | 21 |
| 19270501 | 2009 | Multidrug resistance phenotypes and MRS2 mitochondrial magnesium channel: two players from one stemness? | 7 |
Citation
Dessen P
MRS2 (magnesium transporter MRS2)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41430/mrs2
