MS4A4E (membrane spanning 4-domains A4E)

2014-11-01  

Identity

HGNC
MS4A4E
LOCATION
11q12.2
LOCUSID
643680
ALIAS
-

Other Information

Locus ID:

NCBI: 643680
MIM: 608401
HGNC: 14284

Variants:

dbSNP: 643680
ClinVar: 643680
COSMIC: MS4A4E

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
214608402011Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.685
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
264495412016Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk.8
277813892017Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study.4

Citation

Dessen P

MS4A4E (membrane spanning 4-domains A4E)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70506/ms4a4e