MSLN (mesothelin)

2003-06-01  

Identity

HGNC
MSLN
LOCATION
16p13.3
LOCUSID
10232
ALIAS
MPF,SMRP

Other Information

Locus ID:

NCBI: 10232
MIM: 601051
HGNC: 7371
Ensembl: ENSG00000102854

Variants:

dbSNP: 10232
ClinVar: 10232
TCGA: ENSG00000102854
COSMIC: MSLN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102854ENST00000382862Q13421
ENSG00000102854ENST00000545450Q13421
ENSG00000102854ENST00000561896H3BUX1
ENSG00000102854ENST00000563651H3BR90
ENSG00000102854ENST00000563941Q13421
ENSG00000102854ENST00000566269H3BMA1
ENSG00000102854ENST00000566549Q13421
ENSG00000102854ENST00000569566H3BV92

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
146761942004Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion.168
152179232004Mesothelin: a new target for immunotherapy.152
253786432014Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity.144
170673922006Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors.131
164284852006Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer.74
182815142008Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer.74
236949682013Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation.64
190750182009A binding domain on mesothelin for CA125/MUC16.63
224121412012Serum mesothelin for diagnosing malignant pleural mesothelioma: an individual patient data meta-analysis.60
223714552012Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients.59

Citation

Dessen P

MSLN (mesothelin)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41433/msln