MSRB3 (methionine sulfoxide reductase B3)

2005-02-01  

Identity

HGNC
LOCATION
12q14.3
LOCUSID
ALIAS
DFNB74
FUSION GENES

Other Information

Locus ID:

NCBI: 253827
MIM: 613719
HGNC: 27375
Ensembl: ENSG00000174099

Variants:

dbSNP: 253827
ClinVar: 253827
TCGA: ENSG00000174099
COSMIC: MSRB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174099ENST00000308259Q8IXL7
ENSG00000174099ENST00000355192Q8IXL7
ENSG00000174099ENST00000446731H7C2B7
ENSG00000174099ENST00000535239F5H199
ENSG00000174099ENST00000535664Q8IXL7
ENSG00000174099ENST00000538045F5H7C4
ENSG00000174099ENST00000540804F5H6G9
ENSG00000174099ENST00000541189H0YFW5
ENSG00000174099ENST00000541897F5H4C9
ENSG00000174099ENST00000614640Q8IXL7
ENSG00000174099ENST00000642404Q8IXL7
ENSG00000174099ENST00000642411Q8IXL7
ENSG00000174099ENST00000646299Q8IXL7
ENSG00000174099ENST00000647481A0A2R8Y7J8

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein repairREACTOMER-HSA-5676934

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
224224522012DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth.33
201955142010Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.31
283943292017A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability.28
283892992017MsrB3 deficiency induces cancer cell apoptosis through p53-independent and ER stress-dependent pathways.8
211850092011Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74.0
220270012011Identification of an antimicrobial peptide from human methionine sulfoxide reductase B3.0
223107152012Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila.0
224057672012Methionine sulfoxide reductase B3 protects from endoplasmic reticulum stress in Drosophila and in mammalian cells.0
245832682002Study on the relationship between mitochondrial gene mutation and latent autoimmune diabetes mellitus in adults.0
270591432016Methionine sulfoxide reductase B3 deficiency stimulates heme oxygenase-1 expression via ROS-dependent and Nrf2 activation pathways.0

Citation

Dessen P

MSRB3 (methionine sulfoxide reductase B3)

Atlas Genet Cytogenet Oncol Haematol. 2005-02-01

Online version: http://atlasgeneticsoncology.org/gene/43002/msrb3