MT1A (metallothionein 1A)

2003-08-01  

Identity

HGNC
LOCATION
16q13
LOCUSID
ALIAS
MT-1A,MT-IA,MT1,MT1S,MTC
FUSION GENES

Other Information

Locus ID:

NCBI: 4489
MIM: 156350
HGNC: 7393
Ensembl: ENSG00000205362

Variants:

dbSNP: 4489
ClinVar: 4489
TCGA: ENSG00000205362
COSMIC: MT1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205362ENST00000290705P04731

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
MetabolismREACTOMER-HSA-1430728
Response to metal ionsREACTOMER-HSA-5660526
Metallothioneins bind metalsREACTOMER-HSA-5661231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131285527oxaliplatinChemicalLiterature, MultilinkAnnotationassociated24924344
PA448486arsenic trioxideChemicalLiterature, MultilinkAnnotationassociated24924344

References

Pubmed IDYearTitleCitations
82905671994Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.99
173737312007Metallothionein: an overview.31
183491102008Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.20
182086032008Differential expression of metallothioneins (MTs) 1, 2, and 3 in response to zinc treatment in human prostate normal and malignant cells and tissues.18
195153642009Genetic background of lead and mercury metabolism in a group of medical students in Austria.18
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
268242222016Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc.18
182491472008+647 A/C and +1245 MT1A polymorphisms in the susceptibility of diabetes mellitus and cardiovascular complications.15
182491472008+647 A/C and +1245 MT1A polymorphisms in the susceptibility of diabetes mellitus and cardiovascular complications.15
169552152006Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population.13

Citation

Dessen P

MT1A (metallothionein 1A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41439/mt1a