MT1G (metallothionein 1G)

2007-02-01 Affiliation

Identity

HGNC

MT1G

LOCATION

16q13

LOCUSID

4495

ALIAS

MT1,MT1K

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4495
MIM: 156353
HGNC: 7399
Ensembl: ENSG00000125144

Variants:

dbSNP: 4495
ClinVar: 4495
TCGA: ENSG00000125144
COSMIC: MT1G

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000125144	ENST00000379811	P13640
ENSG00000125144	ENST00000444837	P13640
ENSG00000125144	ENST00000568675	H3BSS0
ENSG00000125144	ENST00000569500	H3BSF1

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Mineral absorption	KEGG	ko04978
Mineral absorption	KEGG	hsa04978
Metabolism	REACTOME	R-HSA-1430728
Response to metal ions	REACTOME	R-HSA-5660526
Metallothioneins bind metals	REACTOME	R-HSA-5661231

References

Pubmed ID	Year	Title	Citations
19491193	2009	Genome-wide screen of promoter methylation identifies novel markers in melanoma.	83
19639168	2009	Detection of metallothionein 1G as a methylated tumor suppressor gene in human hepatocellular carcinoma using a novel method of double combination array analysis.	37
12640681	2003	Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma.	25
19506903	2009	RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China.	23
24782625	2014	MT1M and MT1G promoter methylation as biomarkers for hepatocellular carcinoma.	19
19137073	2008	Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma.	16
20551211	2010	Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.	16
24098937	2013	Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway.	16
24634414	2014	Metallothionein 1G and zinc sensitize human colorectal cancer cells to chemotherapy.	16
18639284	2008	Identification of novel epigenetic markers for clear cell renal cell carcinoma.	14

Citation

Dessen P

MT1G (metallothionein 1G)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43956/mt1g