MT1X (metallothionein 1X)

2013-05-01 Affiliation

Identity

HGNC

MT1X

LOCATION

16q13

LOCUSID

4501

ALIAS

MT-1l,MT1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4501
MIM: 156359
HGNC: 7405
Ensembl: ENSG00000187193

Variants:

dbSNP: 4501
ClinVar: 4501
TCGA: ENSG00000187193
COSMIC: MT1X

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000187193	ENST00000394485	P80297
ENSG00000187193	ENST00000394485	A0A140VJP8
ENSG00000187193	ENST00000562939	U3KQD7
ENSG00000187193	ENST00000564974	U3KQD7

Expression (GTEx)

500

1000

1500

2000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Mineral absorption	KEGG	ko04978
Mineral absorption	KEGG	hsa04978
Metabolism	REACTOME	R-HSA-1430728
Response to metal ions	REACTOME	R-HSA-5660526
Metallothioneins bind metals	REACTOME	R-HSA-5661231

References

Pubmed ID	Year	Title	Citations
22780124	2013	Genome-wide association study of a quantitative disordered gambling trait.	20
20551211	2010	Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.	16
23251525	2012	Microarray-assisted pathway analysis identifies MT1X & NFκB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma.	13
22108904	2012	T([20]) repeat in the 3'-untranslated region of the MT1X gene: a marker with high sensitivity and specificity to detect microsatellite instability in colorectal cancer.	5
20812968	2010	Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro.	3
27107086	2016	Expression of Metallothionein and Vascular Endothelial Growth Factor Isoforms in Breast Cancer Cells.	3
19817957	2009	Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients.	2
24690879	2014	Identification and characterization of MT-1X as a novel FHL3-binding partner.	1
29873415	2018	Metallothionein 1 family profiling identifies MT1X as a tumor suppressor involved in the progression and metastastatic capacity of hepatocellular carcinoma.	1
19881214	2009	[Cilostazol induces metallothionein expression in vascular cells].	0

Citation

Dessen P

MT1X (metallothionein 1X)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53262/mt1x