MT3 (metallothionein 3)

2003-08-01  

Identity

HGNC
LOCATION
16q13
LOCUSID
ALIAS
GIF,GIFB,GRIF,ZnMT3

Other Information

Locus ID:

NCBI: 4504
MIM: 139255
HGNC: 7408
Ensembl: ENSG00000087250

Variants:

dbSNP: 4504
ClinVar: 4504
TCGA: ENSG00000087250
COSMIC: MT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087250ENST00000200691P25713
ENSG00000087250ENST00000200691A0A024R6R7
ENSG00000087250ENST00000561640H3BPK2
ENSG00000087250ENST00000565838H3BQX6
ENSG00000087250ENST00000570176H3BTG5

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Response to metal ionsREACTOMER-HSA-5660526
Metallothioneins bind metalsREACTOMER-HSA-5661231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
209740102010Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes.65
163517312005Metallothionien 3 expression is frequently down-regulated in oesophageal squamous cell carcinoma by DNA methylation.20
125383452003Hypermethylation of metallothionein-3 CpG island in gastric carcinoma.19
182086032008Differential expression of metallothioneins (MTs) 1, 2, and 3 in response to zinc treatment in human prostate normal and malignant cells and tissues.18
237942092013Metallothionein 3: an androgen-upregulated gene enhances cell invasion and tumorigenesis of prostate carcinoma cells.15
185546772008Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner.14
218182862011Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas.14
182066442008PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes.13
118493862002Metallothionein isoform 3 and proximal tubule vectorial active transport.12
259330642015Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression.12

Citation

Dessen P

MT3 (metallothionein 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41442/mt3