MTBP (MDM2 binding protein)

2003-02-01  

Identity

HGNC
MTBP
LOCATION
8q24.12
LOCUSID
27085
ALIAS
MDM2BP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27085
MIM: 605927
HGNC: 7417
Ensembl: ENSG00000172167

Variants:

dbSNP: 27085
ClinVar: 27085
TCGA: ENSG00000172167
COSMIC: MTBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172167ENST00000305949Q96DY7
ENSG00000172167ENST00000519556H0YB28
ENSG00000172167ENST00000523373Q96DY7

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
109061332000A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2.35
156320572005Regulation of p53 and MDM2 activity by MTBP.28
156320572005Regulation of p53 and MDM2 activity by MTBP.28
237045732013Identification of a heteromeric complex that promotes DNA replication origin firing in human cells.27
223706402013MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4.25
247867882014Oncogenic protein MTBP interacts with MYC to promote tumorigenesis.18
216920532011Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck.14
248667692014MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival.12
212740082011MTBP plays a crucial role in mitotic progression and chromosome segregation.10
257592102015MTBP inhibits migration and metastasis of hepatocellular carcinoma.8

Citation

Dessen P

MTBP (MDM2 binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41447/mtbp