MTF1 (metal regulatory transcription factor 1)

2010-03-01  

Identity

HGNC
LOCATION
1p34.3
LOCUSID
ALIAS
MTF-1,ZRF
FUSION GENES

Other Information

Locus ID:

NCBI: 4520
MIM: 600172
HGNC: 7428
Ensembl: ENSG00000188786

Variants:

dbSNP: 4520
ClinVar: 4520
TCGA: ENSG00000188786
COSMIC: MTF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188786ENST00000373036Q14872

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
206889582010Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux.34
119232822002Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription.29
192868432009Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma.27
233687432013Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter.25
175034802007Genetic susceptibility to environmental toxicants in ALS.24
189906862009Regulation of prion gene expression by transcription factors SP1 and metal transcription factor-1.23
153188082004Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison.19
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
268242222016Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc.18
127168932003Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.17

Citation

Dessen P

MTF1 (metal regulatory transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51363/mtf1