MTNR1B (melatonin receptor 1B)

2007-02-01  

Identity

HGNC
MTNR1B
LOCATION
11q14.3
LOCUSID
4544
ALIAS
FGQTL2,MEL-1B-R,MT2

Other Information

Locus ID:

NCBI: 4544
MIM: 600804
HGNC: 7464
Ensembl: ENSG00000134640

Variants:

dbSNP: 4544
ClinVar: 4544
TCGA: ENSG00000134640
COSMIC: MTNR1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134640ENST00000257068P49286
ENSG00000134640ENST00000528076H0YDG4
ENSG00000134640ENST00000532482E9PR36

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
retina
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190609102009Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.337
190609072009Variants in MTNR1B influence fasting glucose levels.298
190609072009Variants in MTNR1B influence fasting glucose levels.298
190609082009Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.229
190609082009Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.229
190609092009A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.217
190609092009A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.217
208586832010Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.170
265516722015Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.132
222862142012Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.113

Citation

Dessen P

MTNR1B (melatonin receptor 1B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45849/mtnr1b