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MTREX (Mtr4 exosome RNA helicase)

Identity

Other aliasDob1
KIAA0052
Mtr4
SKIV2L2
fSAP118
HGNC (Hugo) MTREX
LocusID (NCBI) 23517
Atlas_Id 80523
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 55307748 and ends at 55425581 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)MTREX   18734
Cards
Entrez_Gene (NCBI)MTREX  23517  Mtr4 exosome RNA helicase
AliasesDob1; KIAA0052; Mtr4; SKIV2L2; 
fSAP118
GeneCards (Weizmann)MTREX
Ensembl hg19 (Hinxton)ENSG00000039123 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000039123 [Gene_View]  ENSG00000039123 [Sequence]  chr5:55307748-55425581 [Contig_View]  MTREX [Vega]
ICGC DataPortalENSG00000039123
TCGA cBioPortalMTREX
AceView (NCBI)MTREX
Genatlas (Paris)MTREX
WikiGenes23517
SOURCE (Princeton)MTREX
Genetics Home Reference (NIH)MTREX
Genomic and cartography
GoldenPath hg38 (UCSC)MTREX  -     chr5:55307748-55425581 +  5q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTREX  -     5q11.2   [Description]    (hg19-Feb_2009)
GoldenPathMTREX - 5q11.2 [CytoView hg19]  MTREX - 5q11.2 [CytoView hg38]
ImmunoBaseENSG00000039123
Mapping of homologs : NCBIMTREX [Mapview hg19]  MTREX [Mapview hg38]
OMIM618122   
Gene and transcription
Genbank (Entrez)AK123505 AK291649 AK304788 BC014669 BC028604
RefSeq transcript (Entrez)NM_015360
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MTREX
Cluster EST : UnigeneHs.274531 [ NCBI ]
CGAP (NCI)Hs.274531
Alternative Splicing GalleryENSG00000039123
Gene ExpressionMTREX [ NCBI-GEO ]   MTREX [ EBI - ARRAY_EXPRESS ]   MTREX [ SEEK ]   MTREX [ MEM ]
Gene Expression Viewer (FireBrowse)MTREX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23517
GTEX Portal (Tissue expression)MTREX
Human Protein AtlasENSG00000039123-MTREX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42285   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42285  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42285
Splice isoforms : SwissVarP42285
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusP42285
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    rRNA_proc-arch_dom    Ski2-like    Ski2_C   
Domain families : Pfam (Sanger)DEAD (PF00270)    DSHCT (PF08148)    Helicase_C (PF00271)    rRNA_proc-arch (PF13234)   
Domain families : Pfam (NCBI)pfam00270    pfam08148    pfam00271    pfam13234   
Domain families : Smart (EMBL)DEXDc (SM00487)  DSHCT (SM01142)  HELICc (SM00490)  
Conserved Domain (NCBI)MTREX
DMDM Disease mutations23517
Blocks (Seattle)MTREX
SuperfamilyP42285
Human Protein Atlas [tissue]ENSG00000039123-MTREX [tissue]
Peptide AtlasP42285
IPIIPI00647217   IPI01011073   IPI00815681   IPI00965875   IPI00965573   IPI00964997   
Protein Interaction databases
DIP (DOE-UCLA)P42285
IntAct (EBI)P42285
FunCoupENSG00000039123
BioGRIDMTREX
STRING (EMBL)MTREX
ZODIACMTREX
Ontologies - Pathways
QuickGOP42285
Ontology : AmiGOnuclear exosome (RNase complex)  exosome (RNase complex)  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  maturation of 5.8S rRNA  maturation of 5.8S rRNA  RNA binding  RNA helicase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  rRNA processing  rRNA processing  RNA catabolic process  TRAMP complex  catalytic step 2 spliceosome  
Ontology : EGO-EBInuclear exosome (RNase complex)  exosome (RNase complex)  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  maturation of 5.8S rRNA  maturation of 5.8S rRNA  RNA binding  RNA helicase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  rRNA processing  rRNA processing  RNA catabolic process  TRAMP complex  catalytic step 2 spliceosome  
NDEx NetworkMTREX
Atlas of Cancer Signalling NetworkMTREX
Wikipedia pathwaysMTREX
Orthology - Evolution
OrthoDB23517
GeneTree (enSembl)ENSG00000039123
Phylogenetic Trees/Animal Genes : TreeFamMTREX
HOGENOMP42285
Homologs : HomoloGeneMTREX
Homology/Alignments : Family Browser (UCSC)MTREX
Gene fusions - Rearrangements
Fusion : QuiverMTREX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTREX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTREX
dbVarMTREX
ClinVarMTREX
1000_GenomesMTREX 
Exome Variant ServerMTREX
ExAC (Exome Aggregation Consortium)ENSG00000039123
GNOMAD BrowserENSG00000039123
Varsome BrowserMTREX
Genetic variants : HAPMAP23517
Genomic Variants (DGV)MTREX [DGVbeta]
DECIPHERMTREX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTREX 
Mutations
ICGC Data PortalMTREX 
TCGA Data PortalMTREX 
Broad Tumor PortalMTREX
OASIS PortalMTREX [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMTREX
BioMutasearch MTREX
DgiDB (Drug Gene Interaction Database)MTREX
DoCM (Curated mutations)MTREX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTREX (select a term)
intoGenMTREX
Cancer3DMTREX(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618122   
Orphanet
DisGeNETMTREX
MedgenMTREX
Genetic Testing Registry MTREX
NextProtP42285 [Medical]
TSGene23517
GENETestsMTREX
Target ValidationMTREX
Huge Navigator MTREX [HugePedia]
snp3D : Map Gene to Disease23517
BioCentury BCIQMTREX
ClinGenMTREX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23517
Chemical/Pharm GKB GenePA134901921
Clinical trialMTREX
Miscellaneous
canSAR (ICR)MTREX (select the gene name)
DataMed IndexMTREX
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTREX
EVEXMTREX
GoPubMedMTREX
iHOPMTREX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Sep 3 15:57:04 CEST 2019

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