MTREX (Mtr4 exosome RNA helicase)

2018-11-01  

Identity

HGNC
MTREX
LOCATION
5q11.2
LOCUSID
23517
ALIAS
Dob1,KIAA0052,Mtr4,SKIV2L2,fSAP118

Other Information

Locus ID:

NCBI: 23517
MIM: 618122
HGNC: 18734
Ensembl: ENSG00000039123

Variants:

dbSNP: 23517
ClinVar: 23517
TCGA: ENSG00000039123
COSMIC: MTREX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000039123ENST00000230640P42285
ENSG00000039123ENST00000505565H0Y8U3
ENSG00000039123ENST00000506750D6REC7
ENSG00000039123ENST00000508716H0YAC4

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
TRAMP complexKEGGhsa_M00393
TRAMP complexKEGGM00393
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
278714842016Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts.66
174127072007C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing.62
183093762008Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus.36
287333712017An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression.28
288015092017Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export.28
167820532006The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1.11
264566512015AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74.9
274348182016Interaction properties of human TRAMP-like proteins and their role in pre-rRNA 5'ETS turnover.7
300478662018Distinct and evolutionary conserved structural features of the human nuclear exosome complex.5
308422172019NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.4

Citation

Dessen P

MTREX (Mtr4 exosome RNA helicase)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/80523/mtrex