MTTP (microsomal triglyceride transfer protein)

2003-05-01 Affiliation

Identity

HGNC

MTTP

LOCATION

4q23

LOCUSID

4547

ALIAS

ABL,MTP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4547
MIM: 157147
HGNC: 7467
Ensembl: ENSG00000138823

Variants:

dbSNP: 4547
ClinVar: 4547
TCGA: ENSG00000138823
COSMIC: MTTP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000138823	ENST00000265517	P55157
ENSG00000138823	ENST00000422897	P55157
ENSG00000138823	ENST00000457717	P55157
ENSG00000138823	ENST00000504724	D6RBJ4
ENSG00000138823	ENST00000505094	D6RAB8
ENSG00000138823	ENST00000505142	D6RHZ9
ENSG00000138823	ENST00000506883	D6REL9
ENSG00000138823	ENST00000511045	E9PBP6
ENSG00000138823	ENST00000511610	D6R915
ENSG00000138823	ENST00000513404	D6REP9
ENSG00000138823	ENST00000515141	D6RJG5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Fat digestion and absorption	KEGG	ko04975
Fat digestion and absorption	KEGG	hsa04975
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Lipid digestion, mobilization, and transport	REACTOME	R-HSA-73923
Lipoprotein metabolism	REACTOME	R-HSA-174824
Chylomicron-mediated lipid transport	REACTOME	R-HSA-174800
VLDL interactions	REACTOME	R-HSA-8855121
VLDL biosynthesis	REACTOME	R-HSA-8866423

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA24888	APOA5	Gene	Pathway	associated
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation	associated	PD	15136504
PA444517	Hyperlipoproteinemia Type II	Disease	ClinicalAnnotation	associated	PD	15864113
PA448500	atorvastatin	Chemical	ClinicalAnnotation	associated	PD	15864113
PA451089	pravastatin	Chemical	ClinicalAnnotation	associated	PD	15136504
PA50	APOB	Gene	Pathway	associated
PA51	APOC1	Gene	Pathway	associated
PA52	APOC2	Gene	Pathway	associated
PA53	APOC3	Gene	Pathway	associated
PA55	APOE	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
18497885	2008	FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice.	98
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15094225	2004	Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis.	54
15094225	2004	Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis.	54
15654125	2005	Retina expresses microsomal triglyceride transfer protein: implications for age-related maculopathy.	41
14615589	2003	Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan.	40
15911777	2005	No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans.	40
15337761	2004	Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4.	37
20592474	2010	Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.	33
15504742	2004	Human placenta secretes apolipoprotein B-100-containing lipoproteins.	32

Citation

Dessen P

MTTP (microsomal triglyceride transfer protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41449/mttp