MUC15 (mucin 15, cell surface associated)

2009-09-01  

Identity

HGNC
LOCATION
11p14.2
LOCUSID
ALIAS
MUC-15,PAS3,PASIII

Other Information

Locus ID:

NCBI: 143662
MIM: 608566
HGNC: 14956
Ensembl: ENSG00000169550

Variants:

dbSNP: 143662
ClinVar: 143662
TCGA: ENSG00000169550
COSMIC: MUC15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169550ENST00000281268A0A0A0MTD6
ENSG00000169550ENST00000436318A0A0A0MT67
ENSG00000169550ENST00000455601Q8N387
ENSG00000169550ENST00000527569A0A0A0MTD6
ENSG00000169550ENST00000529533A0A0A0MT67
ENSG00000169550ENST00000648230A0A3B3IU37

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)REACTOMER-HSA-5083632
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)REACTOMER-HSA-5083625
Defective GALNT12 causes colorectal cancer 1 (CRCS1)REACTOMER-HSA-5083636

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375317482023Cell surface associated protein mucin 15 (MUC15) is elevated in preeclampsia.0
375317482023Cell surface associated protein mucin 15 (MUC15) is elevated in preeclampsia.0
352368262022Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis.9
352368262022Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis.9
338943132021MUC15 loss facilitates epithelial-mesenchymal transition and cancer stemness for prostate cancer metastasis through GSK3β/β-catenin signaling.7
338943132021MUC15 loss facilitates epithelial-mesenchymal transition and cancer stemness for prostate cancer metastasis through GSK3β/β-catenin signaling.7
320317022020MUC15 promotes growth and invasion of glioma cells by activating Raf/MEK/ERK pathway.4
323820532020MUC15 inhibits cancer metastasis via PI3K/AKT signaling in renal cell carcinoma.14
324792432020Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives.6
330514322020High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro.2
320317022020MUC15 promotes growth and invasion of glioma cells by activating Raf/MEK/ERK pathway.4
323820532020MUC15 inhibits cancer metastasis via PI3K/AKT signaling in renal cell carcinoma.14
324792432020Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives.6
330514322020High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro.2
255735892015Frameshift mutations of MUC15 gene in gastric and its regional heterogeneity in gastric and colorectal cancers.4

Citation

Dessen P

MUC15 (mucin 15, cell surface associated)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51057/muc15